Huntington disease is a rare dominant condition in humans that results in a slow but inexorable deteriorationof the nervous system. The disease shows what mightbe called age-dependent penetrance, which is to saythat the probability that a person with the Huntingtongenotype will express the phenotype varies with age.Assume that 50% of those inheriting the HD allele willexpress the symptoms by age 40. Susan is a 35-yearold woman whose father has Huntington disease. Shecurrently shows no symptoms. What is the probabilitythat Susan will show symptoms in five years?

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