How to efficiently obtain enantiomerically pure products? - Compare at least two techniques for obtaining pure compounds and highlight their advantages and disadvantages.
How to efficiently obtain enantiomerically pure products? - Compare at least two techniques for obtaining pure compounds and highlight their advantages and disadvantages.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
Enantiomerically pure substances have been the target of investments mainly by the pharmaceutical industry. Cases that occurred in 1961, with the commercialization of Thalidomide as a racemic mixture, showed the importance of enantiomeric purity for the community. Therefore, explain: - How to efficiently obtain enantiomerically pure products? - Compare at least two techniques for obtaining pure compounds and highlight their advantages and disadvantages.
Expert Solution
Step 1
Methods to efficiently obtain enantiomerically pure products are:
1.Gas chromatography (GC),
2.High performance liquid chromatography (HPLC)
3.Supercritical fluid chromatography (SFC)
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