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How can transcription induce hypernegatively supercoiled DNA? Transcription induces negative supercoiling by TCDS. If there is a lot of transcription, it will result in a lot of negative supercoils. Gyrase both transcribes DNA and induces negative supercoils. If there is a lot of gyrase, both transcription and negative supercoiling increase. Transcription causes transient positive supercoiling before the replication bubble. If gyrase is present, it will convert these to negative supercoils. If there is a lot of transcription, this can induce an excess of negative supercoils, unless Topol is there to relax the DNA. RNAP has Type I topoisomerase activity, it induces negative supercoils as it transcribes the DNA.

How can transcription induce hypernegatively supercoiled DNA? Transcription induces negative supercoiling by TCDS. If there is a lot of transcription, it will result in a lot of negative supercoils. Gyrase both transcribes DNA and induces negative supercoils. If there is a lot of gyrase, both transcription and negative supercoiling increase. Transcription causes transient positive supercoiling before the replication bubble. If gyrase is present, it will convert these to negative supercoils. If there is a lot of transcription, this can induce an excess of negative supercoils, unless Topol is there to relax the DNA. RNAP has Type I topoisomerase activity, it induces negative supercoils as it transcribes the DNA.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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How can transcription induce hypernegatively supercoiled DNA? Transcription induces negative supercoiling by TCDS. If there is a lot of transcription, it will result in a lot of negative supercoils. Gyrase both transcribes DNA and induces negative supercoils. If there is a lot of gyrase, both transcription and negative supercoiling increase. Transcription causes transient positive supercoiling before the replication bubble. If gyrase is present, it will convert these to negative supercoils. If there is a lot of transcription, this can induce an excess of negative supercoils, unless Topol is there to relax the DNA. RNAP has Type I topoisomerase activity, it induces negative supercoils as it transcribes the DNA.
Transcribed Image Text:How can transcription induce hypernegatively supercoiled DNA? Transcription induces negative supercoiling by TCDS. If there is a lot of transcription, it will result in a lot of negative supercoils. Gyrase both transcribes DNA and induces negative supercoils. If there is a lot of gyrase, both transcription and negative supercoiling increase. Transcription causes transient positive supercoiling before the replication bubble. If gyrase is present, it will convert these to negative supercoils. If there is a lot of transcription, this can induce an excess of negative supercoils, unless Topol is there to relax the DNA. RNAP has Type I topoisomerase activity, it induces negative supercoils as it transcribes the DNA.
Lacl binds the lacZY promoter at the lacO. What does this binding event do? Prevents Sigma A-RNAP from binding the -10 and -35 sites of the promoter Blocks the ribosome from translating LacZ and LacY Prevents CAP-CAMP from binding the promoter Allows CAP-CAMP to bind the promoter
Transcribed Image Text:Lacl binds the lacZY promoter at the lacO. What does this binding event do? Prevents Sigma A-RNAP from binding the -10 and -35 sites of the promoter Blocks the ribosome from translating LacZ and LacY Prevents CAP-CAMP from binding the promoter Allows CAP-CAMP to bind the promoter
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Step 1

Lac operon in presence of lactose, binds to the repressor protein and inactivates the repressor proteins, and prevents its binding to the promoter. This leaves the space for DNA polymerase to binds to the promoter and initiates the transcription of genes Z, Y, A. 

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