Why and how do the polymerase go backward from state 2 (post-translocation state) to state 1(pre-translocation state) during replication and transcription?
Why and how do the polymerase go backward from state 2 (post-translocation state) to state 1(pre-translocation state) during replication and transcription?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Why and how do the polymerase go backward from state 2 (post-translocation state) to state 1(pre-translocation state) during replication and transcription?
![km+/ niu
Product
Substrate(non-cognate/wrong)
IIIW
Err*kö-
(1-Err) KII-
km+
Err*k₁-
mini
(1-Err) K₁-
(1-i,) k₁+
i₁ kµ+
kun-in
Err*k₁+
(1-Err) KI+
III™
Substrate(cognate/right)
ki-
Reactant
Figure 1. The kinetic scheme for the three-state nucleotide addition cycle (NAC) with selection.
Since the cognate (right) and non-cognate (wrong) nucleotide species are differentiated in the
substrate state III, one splits the cycle into two pathways for the right and wrong substrate species.
Correspondingly, one has a population vector II : (P₁, P₁, P, PW) to describe the overall state
probability distributions.
=
III](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff03e33e4-bbf4-4f17-aa67-9748ad2e036a%2F61d80e8d-37ff-47ed-a469-0bbf600534b7%2Fya5t7h9_processed.png&w=3840&q=75)
Transcribed Image Text:km+/ niu
Product
Substrate(non-cognate/wrong)
IIIW
Err*kö-
(1-Err) KII-
km+
Err*k₁-
mini
(1-Err) K₁-
(1-i,) k₁+
i₁ kµ+
kun-in
Err*k₁+
(1-Err) KI+
III™
Substrate(cognate/right)
ki-
Reactant
Figure 1. The kinetic scheme for the three-state nucleotide addition cycle (NAC) with selection.
Since the cognate (right) and non-cognate (wrong) nucleotide species are differentiated in the
substrate state III, one splits the cycle into two pathways for the right and wrong substrate species.
Correspondingly, one has a population vector II : (P₁, P₁, P, PW) to describe the overall state
probability distributions.
=
III
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