following data were obtained: - Surface area of diffusion = 33.4 cm2 - Original concentration = 1.7 mg/mL - The permeability coefficient = 3.85 x 10-6 cm/s a) Calculate the amount of drug that will permeate in 4.5 hours if the experiment was carried out under sink conditions. b) Is the system working under steady-state conditions? Explain.
following data were obtained: - Surface area of diffusion = 33.4 cm2 - Original concentration = 1.7 mg/mL - The permeability coefficient = 3.85 x 10-6 cm/s a) Calculate the amount of drug that will permeate in 4.5 hours if the experiment was carried out under sink conditions. b) Is the system working under steady-state conditions? Explain.
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 7.8P
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Question
![Q.1) To study the oral absorption of certain
drug from an oil-water emulsion formulation,
the
following data were obtained:
- Surface area of diffusion = 33.4 cm2
- Original concentration = 1.7 mg/mL
- The permeability coefficient = 3.85 x 10-6
cm/s
a) Calculate the amount of drug that will
permeate in 4.5 hours if the experiment was
carried
out under sink conditions.
b) Is the system working under steady-state
conditions? Explain.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F8799471b-cdcc-404a-a034-89f617806c2c%2Ffc513e82-1e59-4f4e-b3a3-fc60798803a3%2F1m0ohzm_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Q.1) To study the oral absorption of certain
drug from an oil-water emulsion formulation,
the
following data were obtained:
- Surface area of diffusion = 33.4 cm2
- Original concentration = 1.7 mg/mL
- The permeability coefficient = 3.85 x 10-6
cm/s
a) Calculate the amount of drug that will
permeate in 4.5 hours if the experiment was
carried
out under sink conditions.
b) Is the system working under steady-state
conditions? Explain.
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