following data were obtained: - Surface area of diffusion = 33.4 cm2 - Original concentration = 1.7 mg/mL - The permeability coefficient = 3.85 x 10-6 cm/s a) Calculate the amount of drug that will permeate in 4.5 hours if the experiment was carried out under sink conditions. b) Is the system working under steady-state conditions? Explain.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Q.1) To study the oral absorption of certain
drug from an oil-water emulsion formulation,
the
following data were obtained:
- Surface area of diffusion = 33.4 cm2
- Original concentration = 1.7 mg/mL
- The permeability coefficient = 3.85 x 10-6
cm/s
a) Calculate the amount of drug that will
permeate in 4.5 hours if the experiment was
carried
out under sink conditions.
b) Is the system working under steady-state
conditions? Explain.
Transcribed Image Text:Q.1) To study the oral absorption of certain drug from an oil-water emulsion formulation, the following data were obtained: - Surface area of diffusion = 33.4 cm2 - Original concentration = 1.7 mg/mL - The permeability coefficient = 3.85 x 10-6 cm/s a) Calculate the amount of drug that will permeate in 4.5 hours if the experiment was carried out under sink conditions. b) Is the system working under steady-state conditions? Explain.
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