Polymer nanoparticles, Microparticles and hydrogels have been developed for slow and sustained drug release for slow and sustained drug release application; mark all that apply below: 1)Drug release from hydrogels can be via (a) drug diffusion, (b) degradation of the polymeric matrix and (c) swelling 2) PLGA degrades to lactic acid and glycolic acid, which are not biocompatible 3) Drug release can be triggered through internal and external stimuli - I.e. by use of pH labile chemistries or external triggers 4) Burst release describes the initial faster release rates often observed in drug delivery system, which is then followed by sustained release 5) while burst release is observed with polymer nanoparticles, it is not observed from hydrogels
1)Drug release from hydrogels can be via (a) drug diffusion, (b) degradation of the
2) PLGA degrades to lactic acid and glycolic acid, which are not biocompatible
3) Drug release can be triggered through internal and external stimuli - I.e. by use of pH labile chemistries or external triggers
4) Burst release describes the initial faster release rates often observed in drug delivery system, which is then followed by sustained release
5) while burst release is observed with polymer nanoparticles, it is not observed from hydrogels
Drug delivery systems are designed to deliver a therapeutic agent to the patient in a controlled and effective manner. Sustained release drug delivery systems are particularly advantageous, as they can maintain therapeutic drug levels over an extended period of time, reducing the need for frequent dosing.
Hydrogels and polymer nanoparticles are two common types of drug delivery systems that can be used for sustained release. Hydrogels are three-dimensional networks of hydrophilic polymers that can swell when exposed to water. Polymer nanoparticles are small particles (typically less than 1000 nm in diameter) that are made from synthetic or natural polymers.
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