Explain the concept of loss of heterozygosity (LOH). Why do most cancer cells exhibit LOH of one or more genes? How does failure of the spindle assembly checkpoint lead to loss of heterozygosity?

Q: Describe what happens to the G1 cell cycle check point of a skin cell that is stimulated to divide…

A: Transformation of cells from one phase of the cell cycle to another is controlled by some external…

Q: The protein p53 is activated when the cell's DNA is damaged. p53 helps to arrest the cell cycle in…

A: Cell division is controlled by a protein that is encoded by a tumor suppressor gene. Uncontrolled…

Q: How is an inmortal cancer cell line different from a regular cancel cell line ?

A: Cancerous cells : In our body cell division and differentiation is a highly regulated and controlled…

Q: #1)  Hyperplastic growth are not cancerous yet but show a higher than normal proliferation rate.…

A: ANSWER) TRUE Hyperplastic growth is the increase in the number of cells and therefore the…

Q: rms of the cell cycle, what would happen if there was a defect in the Rb prote made it unable to…

A: Rb protein is a tumor suppressor protein that is it suppresses the tumor from growing. Hence Rb…

Q: Match each of the changes that can contribute to cancer with its correct description. Loss of…

A: Cancer is a disease where the cells grow uncontrollably. It may affect any part of the body and…

Q: Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb?…

A: Cell division is a process through which a cell produces two identical daughter cells. Cell division…

Q: The following figure shows how the activities (y-axis) of Cdk-Cyclin B complex and the APC complex…

A: * Mitosis is type of cell division where cell divides into two which gives genetically identical…

Q: Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell…

A: Need to find all the options that produce uncontrollable cell division  and to increase chance of…

Q: What is happening in all cancer? What process is this disrupting?

A: Cancer in simple term can be referred to a set of diseases which are caused by the production of an…

Q: How do cyclins and Cdk's drive progression through different phases of the cell cycle?

A: Every multicellular organism that is found on earth start their life as a single cell which is…

Q: The epidermal growth factor receptor (EGFR) activates a complex signaling network to increase…

A: Answer  C-myc synthesis is responsible for cell growth and development and prevent apoptosis.…

Q: Out of these 8 hallmarks ( sustaining proliferative signaling, evading growth suppressors, resisting…

A: The cells multiply by cell division. It is a controlled process for the growth and development of…

Q: BRCA1 and BRCA2 are genes that encode proteins involved in DNA repair. If DNA can not be repaired,…

A: BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that make proteins that aid…

Q: Exposure to test compounds for several days is commonly used to determine if they cause an…

A: Cell proliferation inhibition was estimated by MTT assay. The occurrence of apoptosis was evaluated…

Q: What is a method some tumors use to evade restriction of their growth by secreting substances that…

A: Cells are the part of human body which grows and divide to make new cells. They are the basic…

Q: What is required to enable a cancercell to metastasize?

A: INTRODUCTION: Metastasis means that cancer cell spreads to a different body part from where it has…

Q: Do cells which lack normal cell cycle control (cancerous cells) exhibit karyotypes that look…

A: Karyotype  It is a process in which the structure of chromosome is depicted. Or in general,…

Q: Taxol, derived from the Pacific Yew tree, was one of the first effective anti-cancer compounds…

A: Taxol is an anti-cancer chemotherapy drug.Taxol is classified as a "plant alkaloid".It is an…

Q: Which cells are shown in the figure below (under the X) ?

A: Cardiac muscle Cardiac muscle also known as heart muscles or myocardium. The heart of human being is…

Q: During growth, can a patch of tissue with a white phenotype give rise to a patch with a green…

A: Plants are multicellular organisms in the kingdom Plantae. Plants have an essential role in the…

Q: Excessive angiogenesis and reduced apoptosis are two of the six characteristics that define…

A: Angiogenesis:  Angiogenesis refers to the process of the growth and development of new blood vessels…

Q: In other words, the master regulator initiates a program of gene expression that narrow the…

A: Cell signalling

Q: In attempting to design a drug that will impede cell cycle progression in ovarian cancers cells. you…

A: The answer is none of these.The cell cycle is a tightly regulated process that controls the growth…

Q: Choose the letter of the best match from the following. A. Spindle Checkpoint B. Checkpoint to look…

A: G1= C.Time of the most cell growth(longest and first phase of the cell cycle ) S=E. Duplicate copy…

Q: Explain in detail two different genetic mutations that can promote the development of cancer.…

A: A mutation in a gene that codes for a protein involved in a crucial biological process, such as DNA…

Q: Select the statements that accurately describe different ways that translocations could lead to…

A: Answer-  (A) A translocation breaks up the sequence of a gene for a protein that stimulates…

Q: Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote…

A: It codes for a protein or a functional product rRNA (ribosomal RNA) or tRNA (transfer RNA). DNA is…

Q: When regulating the cell cycle of eukaryotic cells, a critical protein we discussed was cyclin.…

A: Cyclins are a type of protein that do not have any enzymatic activity on their own but cyclins bind…

Q: Identify one way in which a specific cancer evades the controls of the cell cycle.

A: One of the major components of control in the cell cycle is Apoptosis. It is the process of…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.