Examining Table 20-4, what do you think would be the order of mutations fixed during selection in a third evolving virus line? Would the mutations become fixed in the same order as the TX or ID virus?

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Examining Table 20-4, what do you think would be the
order of mutations fixed during selection in a third evolving virus line? Would the mutations become fixed in the
same order as the TX or ID virus?

TABLE 20-4 Molecular Substitutions in Two 4-X174 Bacteriophages,
TX and ID, During Adaptation
Order*
TX site
Amino acid change
ID site
Amino acid change
1
782
E72, T → 1
2167
F388, H – Q
F204, T → S
F177, T →I
2
1727
F242, L→ F
F361, А — V
С63, V— F
Н15, G — S
C64, D → G
1613
3
2085
15336
4
319
1460
F153, Q → E
F99, silent
2973
1300
6
323
13053
F101, G → D
F102, Y → C
А44, Н — Ү
A219, silent
А44, Н — Ү
F8, E – K
НH79, А — V
А402, Т — М
F101, G → D
deletion
7
41103
1308
8
1025
4110'
9
31667
4637
10
5185
965-914
deletion
11
13052
53655
А462, М — Т
12
965-914
41687
A63, Q → R
H79, A → V
А462, М — Т
F177, T →I
А63, Q — R
13
53655
3166²
14
1533!
1809
F269, К — R
15
41686
*Changes are listed in the order in which they appeared in each of the two bacteriophage
selection lines. The nucleotide position is listed, followed by the protein affected, A-H,
with the number of the amino acid residue and the nature of the amino acid substitution.
Parallel changes are shown in boldface, and a superscript indicates the order of those
changes in the other virus selection line.
Source: H. A. Wichman et al., Science 285, 1999, 422-424.
Transcribed Image Text:TABLE 20-4 Molecular Substitutions in Two 4-X174 Bacteriophages, TX and ID, During Adaptation Order* TX site Amino acid change ID site Amino acid change 1 782 E72, T → 1 2167 F388, H – Q F204, T → S F177, T →I 2 1727 F242, L→ F F361, А — V С63, V— F Н15, G — S C64, D → G 1613 3 2085 15336 4 319 1460 F153, Q → E F99, silent 2973 1300 6 323 13053 F101, G → D F102, Y → C А44, Н — Ү A219, silent А44, Н — Ү F8, E – K НH79, А — V А402, Т — М F101, G → D deletion 7 41103 1308 8 1025 4110' 9 31667 4637 10 5185 965-914 deletion 11 13052 53655 А462, М — Т 12 965-914 41687 A63, Q → R H79, A → V А462, М — Т F177, T →I А63, Q — R 13 53655 3166² 14 1533! 1809 F269, К — R 15 41686 *Changes are listed in the order in which they appeared in each of the two bacteriophage selection lines. The nucleotide position is listed, followed by the protein affected, A-H, with the number of the amino acid residue and the nature of the amino acid substitution. Parallel changes are shown in boldface, and a superscript indicates the order of those changes in the other virus selection line. Source: H. A. Wichman et al., Science 285, 1999, 422-424.
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