Draw the major product formed for each reaction. (a) The conjugate acid of triethylamine has a pKa -11, the pKa of the most acidic sites of the substrate is ~20. (b) (c) H3C CH3 CH3 H3C. then CH3l H3C Cu-Li ㅅ H3C CH3 then O H3C OCH3 CH3 LDA ++ H3C CH3 then H3C 요. H U-3H 03H
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- Which carboxylate is the strongest base?22) NM₂2 in N,N-dimethylaniline ( is ortho-para director but it gives meta product in reaction with one of the following reagents. Identify the reagent. a) Br₂ b) c) HNO3 H₂SO4 O اتFluvastatin, a cholesterol-lowering drug, can be prepared by thefollowing three-step reaction sequence. Identify intermediates A and Band the final product, fluvastatin.
- Please all solutionPQ-28. What is the major product of this reaction? (A) (C) ОН ОН H3CH₂ CH₂CH3 (B) (D) 1) CH3CH₂MgBr 2) NHA HO CH₂CH3 ОНElectrostatic potential maps of anisole and thioanisole are shown. Which do you think is the stronger acid, p-methoxybenzoic acid or p-(methylthio)benzoic acid? Explain.
- Naturally occurring compounds called cyanogenic glycosides, such as lotaustralin, release hydrogen cyanide, HCN, when treated with aqueous acid. The reaction occurs by hydrolysis of the acetal linkage to form a cyanohydrin, which then expels HCN and gives a carbonyl compound. (a) Show the mechanism of the acetal hydrolysis and the structure of the cyanohydrin that results. (b) Propose a mechanism for the loss of HCN, and show the structure of the carbonyl compound that forms.The following three derivatives of succinimide are anticonvulsants that have found use in the treatment of epilepsy, particularly petit mal seizures. Q. Propose experimental conditions for the conversion of (C) to (D).PQ-17. What is the major product of this reaction? (A) H3CO њсоян (B) OH OH (C) OH O H OH OH 1) CH,MgBr (1 eq.) 2) NHÀ -OH (D) онян
- Phthalic acid and isophthalic acid have protons on two carboxy groups that can be removed with base. (a) Explain why the pKa for loss of the first proton (pKa1) is lower for phthalic acid than isophthalic acid. (b) Explain why the pKa for loss of the second proton (pKa2) is higher for phthalic acid than isophthalic acid.(a) (b) (c) (d) (e) + Lysine H₂O + Hopi HO3P- HO OH i O: N OH A + HSCH 3 OH acetal formation imine formation enamine hydrolysis acyl substitution 1,4 additionPhthalic acid and isophthalic acid have protons on two carboxy groups that can be removed with base. (a) Explain why the pKa for loss of the first proton (pKa1) is lower for phthalic acid than isophthalic acid. (b) Explain why the pKa for loss of the second proton (pKa2) is higher for phthalic acid than isophthalic acid.