Diisopropyl fluorophosphate (DFP) inhibit acetylcholinesterase activity by reacting covalently to a serine residue found within the active site of the enzyme. The physiological effect of this inactivation is interference with neurotransmitter inactivation at the synapses of nerves, resulting in the constant propagation of nerve impulses, which can lead to death. What type of inhibitor is DFP? Explain.
Diisopropyl fluorophosphate (DFP) inhibit acetylcholinesterase activity by reacting covalently to a serine residue found within the active site of the enzyme. The physiological effect of this inactivation is interference with neurotransmitter inactivation at the synapses of nerves, resulting in the constant propagation of nerve impulses, which can lead to death. What type of inhibitor is DFP? Explain.
Biochemistry
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Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Diisopropyl fluorophosphate (DFP) inhibit acetylcholinesterase activity by reacting covalently to a serine residue found within the active site of the enzyme. The physiological effect of this inactivation is interference with neurotransmitter inactivation at the synapses of nerves, resulting in the constant propagation of nerve impulses, which can lead to death. What type of inhibitor is DFP? Explain.
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