Devise a synthesis of CH3CH₂CH₂CHO from two-carbon starting materials. Be sure to answer all parts. Step 1: HC=CH HC—CH Intermediate 1: draw structure ... Step 2: H₂O H₂ SO 4 HgSO4 BrCH₂ CH₂OH Br2 HBr HC–CH NaNI HCCH CH3 CH₂ Br (2 equiv) NaH [1] BH3 [2] H₂O₂, HO
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![Devise a synthesis of CH3CH₂CH₂CHO from two-carbon starting materials. Be sure to answer all
parts.
Step 1:
O
HC—CH
HC=CH
Intermediate 1:
draw structure.
Step 2:
H₂O
***
H₂SO4
HgSO4
BrCH₂ CH₂OH
Br2
HBr
HC=CH
NaNH
HC=_CH
CH3 CH₂ Br
(2 equiv)
NaH
[1] BH3
[2] H₂O₂, HO](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F420356ae-6511-4d5c-a34c-01ae4c070f4a%2F63f1e88b-5d8b-401a-a75f-5f7ef0d507e0%2Fffvqrv5o_processed.jpeg&w=3840&q=75)
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