DATA SET 01 The number of offspring in F1 and F2 generations: 510 The true mode of inheritance is autosomal dominant. Parental cross: Father with disease phenotype, Mother with wild-type phenotype.   F1 COUNTS FOR DATA SET 01 Phenotype Gender.   Disease     Wild-Type   Male        237             0 Female       273             0   F2 COUNTS FOR DATA SET 01 Phenotype Gender    Disease     Wild-Type   Male             185               73 Female           183               69   DATA SET 02 The number of offspring in F1 and F2 generations: 899 F1 COUNTS FOR DATA SET 02 Phenotype Gender   Disease      Wild-Type   Male          424           0 Female          475         0   F2 COUNTS FOR DATA SET 02 Phenotype Gender      Disease      Wild-Type   Male             349             112 Female           323             115 F2 COUNTS FOR DATA SET 01 Gender Phenotype Observed counts (O)  Expected Proportions  Expected Counts (E)  (O-E)  (O-E)^2/E  Male WT 73         Male Disease 185         Female WT 69         Female Disease 183         Total   510                   DegFrdm             P-value     F2 COUNTS FOR DATA SET 02 Gender Phenotype Observed counts (O)  Expected Proportions  Expected Counts (E)  (O-E)  (O-E)^2/E  Male WT 112         Male Disease 349         Female WT 115         Female Disease 323         Total   899                   DegFrdm             P-value     Can you please do the same in this example and fill in those two tables, please typed  The solution should be like this one ????????

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DATA SET 01

The number of offspring in F1 and F2 generations: 510

The true mode of inheritance is autosomal dominant.

Parental cross: Father with disease phenotype, Mother with wild-type phenotype.

 

F1 COUNTS FOR DATA SET 01

Phenotype

Gender.   Disease     Wild-Type

  Male        237             0

Female       273             0

 

F2 COUNTS FOR DATA SET 01

Phenotype

Gender    Disease     Wild-Type

  Male             185               73

Female           183               69

 

DATA SET 02

The number of offspring in F1 and F2 generations: 899

F1 COUNTS FOR DATA SET 02

Phenotype

Gender   Disease      Wild-Type

  Male          424           0

Female          475         0

 

F2 COUNTS FOR DATA SET 02

Phenotype

Gender      Disease      Wild-Type

  Male             349             112

Female           323             115

F2 COUNTS FOR DATA SET 01

Gender Phenotype Observed
counts
(O) 
Expected
Proportions 
Expected
Counts
(E) 
(O-E)  (O-E)^2/E 
Male WT 73        
Male Disease 185        
Female WT 69        
Female Disease 183        
Total   510        
          DegFrdm  
          P-value  

 

F2 COUNTS FOR DATA SET 02

Gender Phenotype Observed
counts
(O) 
Expected
Proportions 
Expected
Counts
(E) 
(O-E)  (O-E)^2/E 
Male WT 112        
Male Disease 349        
Female WT 115        
Female Disease 323        
Total   899        
          DegFrdm  
          P-value  

 

Can you please do the same in this example and fill in those two tables, please typed 

The solution should be like this one ????????

 

 

The number of offspring in F1 and F2 generations: 854
Punnett Square for Fi parents.
Mother's alleles
Father's alleles
d.
d
D
Dd
Dd
d
dd
dd
From intro, we know that WT must be homozygous, and because we are dealing with Autosomal
Dominant, Homozygous Lethal, other parent must be Dd. This table is identical to parental Punnett
square.
So, according to Punnett Square, F1 generation has 50% disease, 50% WT. Multiply by ½ to get male and
female, or 25% for each.
F1 COUNTS FOR DATA SET 02
Phenotype
Gender Disease Wild-Type
Male 209
213
Female 223
209
F2 COUNTS FOR DATA SET 02
2 |Page
Phenotype
Gender Disease Wild-Type
Male 219
182
Female 213
240
F2 CHI-SQUARE TEST ANALYSIS WITH TRUE MOI
Table for compute X^2 Goodness of Fit value
Phenotype
ObsCounts(O) ExpProp
ExpCounts(E) (О-Е)
213,5
213,5
213,5
213,5
(O-E)^2/E
-31.5
5.5
26,5
Male
WT
182
219
4.6475
0.14169
0.25
Male Disease
0.25
Female
Female Disease
WT
240
0.25
3.2892
213
0.25
-0.5
0.001171
X^2 Goodness-of-fit Statistic : 8.07962529
Degrees of freedom
P-value
:
3
:0.0443944375
P-value < 0.05. Reject null hypothesis
for your specified mode of inheritance.
So, data set most consistent with MOI is Data Set 01, since we do not reject the null hypothesis, and we
do in Data Set 02.
Transcribed Image Text:The number of offspring in F1 and F2 generations: 854 Punnett Square for Fi parents. Mother's alleles Father's alleles d. d D Dd Dd d dd dd From intro, we know that WT must be homozygous, and because we are dealing with Autosomal Dominant, Homozygous Lethal, other parent must be Dd. This table is identical to parental Punnett square. So, according to Punnett Square, F1 generation has 50% disease, 50% WT. Multiply by ½ to get male and female, or 25% for each. F1 COUNTS FOR DATA SET 02 Phenotype Gender Disease Wild-Type Male 209 213 Female 223 209 F2 COUNTS FOR DATA SET 02 2 |Page Phenotype Gender Disease Wild-Type Male 219 182 Female 213 240 F2 CHI-SQUARE TEST ANALYSIS WITH TRUE MOI Table for compute X^2 Goodness of Fit value Phenotype ObsCounts(O) ExpProp ExpCounts(E) (О-Е) 213,5 213,5 213,5 213,5 (O-E)^2/E -31.5 5.5 26,5 Male WT 182 219 4.6475 0.14169 0.25 Male Disease 0.25 Female Female Disease WT 240 0.25 3.2892 213 0.25 -0.5 0.001171 X^2 Goodness-of-fit Statistic : 8.07962529 Degrees of freedom P-value : 3 :0.0443944375 P-value < 0.05. Reject null hypothesis for your specified mode of inheritance. So, data set most consistent with MOI is Data Set 01, since we do not reject the null hypothesis, and we do in Data Set 02.
Parental cross: Father with disease phenotype, Mother with wild-type phenotype.
F1 COUNTS FOR DATA SET 01
Punnett Square for Parents:
Mother's alleles
Father's alleles
d
d
D
Dd
Dd
d
dd
dd
According to Punnett Square, F1 generation has 50% disease, 50% WT. Multiply by ½ to get male and
female.
Phenotype
Gender Disease Wild-Type
Male 133
133
Female 118
118
Punnett Square for Parents:
Mother's alleles
Father's alleles
d
Dd
Dd
d
PP
dd
dd
From intro, we know that WT must be homozygous, and because we are dealing with Autosomal
Dominant, Homozygous Lethal, other parent must be Dd. This table is identical to parental Punnett
square.
So, according to Punnett Square, F1 generation has 50% disease, 50% WT. Multiply by ½ to get male and
female, or 25% for each.
1| Page
F2 COUNTS FOR DATA SET 01
Phenotype
Gender Disease Wild-Type
Male 123
121
Female 144
114
F2 CHI-SQUARE TEST ANALYSIS WITH TRUE MỌI
Table for compute X^2 Goodness of Fit value
Phenotype
ObsCounts(O) ExpProp
ExpCounts(E) (O-E)
125.5
(O-E)^2/E
0.16135
0.049801
Male
WT
121
0.25
-4.5
-2.5
-11.5
Male Disease
123
0.25
125.5
Female WT
114
0.25
125.5
1.0538
Female Disease
144
0.25
125.5
18.5
2.7271
X^2 Goodness-of-fit Statistic: 3.99203187
Degrees of freedom
P-value
: 3
0.26232583
P-value > 0.05. Do not reject null hypothesis for your specified mode of inheritance.
DATA SET 02
The number of offspring in F1 and F2 generations: 854
Transcribed Image Text:Parental cross: Father with disease phenotype, Mother with wild-type phenotype. F1 COUNTS FOR DATA SET 01 Punnett Square for Parents: Mother's alleles Father's alleles d d D Dd Dd d dd dd According to Punnett Square, F1 generation has 50% disease, 50% WT. Multiply by ½ to get male and female. Phenotype Gender Disease Wild-Type Male 133 133 Female 118 118 Punnett Square for Parents: Mother's alleles Father's alleles d Dd Dd d PP dd dd From intro, we know that WT must be homozygous, and because we are dealing with Autosomal Dominant, Homozygous Lethal, other parent must be Dd. This table is identical to parental Punnett square. So, according to Punnett Square, F1 generation has 50% disease, 50% WT. Multiply by ½ to get male and female, or 25% for each. 1| Page F2 COUNTS FOR DATA SET 01 Phenotype Gender Disease Wild-Type Male 123 121 Female 144 114 F2 CHI-SQUARE TEST ANALYSIS WITH TRUE MỌI Table for compute X^2 Goodness of Fit value Phenotype ObsCounts(O) ExpProp ExpCounts(E) (O-E) 125.5 (O-E)^2/E 0.16135 0.049801 Male WT 121 0.25 -4.5 -2.5 -11.5 Male Disease 123 0.25 125.5 Female WT 114 0.25 125.5 1.0538 Female Disease 144 0.25 125.5 18.5 2.7271 X^2 Goodness-of-fit Statistic: 3.99203187 Degrees of freedom P-value : 3 0.26232583 P-value > 0.05. Do not reject null hypothesis for your specified mode of inheritance. DATA SET 02 The number of offspring in F1 and F2 generations: 854
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