In this section population data on the incidence of Down syndrome in relation to mother's age will be analysed in detail. These observations should allow you to more fully understand the statistical probability of this common autosomal aneuploidy (which you will learn more about in week 11). The population data in Table 1 shows the total number of children born and the number of Down syndrome children born to mothers who have been classified into single year intervals of their age at the time of birth. The data are from residents of British Columbia, Canada and were collected for the years 1961 to 1970. (Note: This was before prenatal diagnosis was available.) Q8. Calculate the overall rate of occurrence of Down syndrome per 1,000 births. Give your answer to two decimal places. Q9. It is sometimes forgotten that many Down syndrome children are born to younger mothers. What percentage of Down syndrome children in the British Columbia study were born to mothers younger than 37 years? Give a whole-number, no decimal places. Q10. If 2,000 children are born each year in Victoria to mothers who will be 37 years or older, and if the mother's age distribution follows that of the British Columbia study, how many Down syndrome children would be born to such mothers in one year (in the absence of prenatai diagnosis and intervention)? Give a whole-number, no decimal places.
In this section population data on the incidence of Down syndrome in relation to mother's age will be analysed in detail. These observations should allow you to more fully understand the statistical probability of this common autosomal aneuploidy (which you will learn more about in week 11). The population data in Table 1 shows the total number of children born and the number of Down syndrome children born to mothers who have been classified into single year intervals of their age at the time of birth. The data are from residents of British Columbia, Canada and were collected for the years 1961 to 1970. (Note: This was before prenatal diagnosis was available.) Q8. Calculate the overall rate of occurrence of Down syndrome per 1,000 births. Give your answer to two decimal places. Q9. It is sometimes forgotten that many Down syndrome children are born to younger mothers. What percentage of Down syndrome children in the British Columbia study were born to mothers younger than 37 years? Give a whole-number, no decimal places. Q10. If 2,000 children are born each year in Victoria to mothers who will be 37 years or older, and if the mother's age distribution follows that of the British Columbia study, how many Down syndrome children would be born to such mothers in one year (in the absence of prenatai diagnosis and intervention)? Give a whole-number, no decimal places.
Chapter5: The Infectious Process And Environmental Control
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Transcribed Image Text:Table 1: DOWN SYNDROME BY SINGLE-YEAR INTERVAL
Down syndrome live births, and estimated total live births, for British Columbia residents,
1961-1970
Matemal age
in years
Sum total of
live births
Sum total
of cases
S17
18
19
13,555
13,675
18,752
16
15
16
20
21
22,005
23,896
24,667
24,807
23,986
22
16
12
17
22
22
23
24
25
26
27
28
29
22,860
21,450
19,202
17,450
15,685
15
14
27
14
9
30
31
32
33
34
13,954
11,987
10,983
9,825
8,483
12
12
18
13
11
35
36
37
38
39
7,448
6,628
5,780
4,834
3,961
23
13
17
15
30
2,952
2,276
1,589
1,018
596
40
31
41
33
20
16
22
42
43
44
45
246
327
249
11
7
Total
354,880
519
*5 mothers of age 46 years, 2 mothers of age 47 years with Down syndrome live births.
Transcribed Image Text:In this section population data on the incidence of Down syndrome in relation to mother's age
will be analysed in detail. These observations should allow you to more fully understand the
statistical probability of this common autosomal aneuploidy (which you will learn more about
in week 11).
The population data in Table 1 shows the total number of children born and the number of
Down syndrome children born to mothers who have been classified into single year intervals
of their age at the time of birth. The data are from residents of British Columbia, Canada and
were collected for the years 1961 to 1970. (Note: This was before prenatal diagnosis was
available.)
Q8. Calculate the overall rate of occurrence of Down syndrome per 1,000 births. Give your
answer to two decimal places.
Q9. It is sometimes forgotten that many Down syndrome children are born to younger mothers.
What percentage of Down syndrome children in the British Columbia study were born to
mothers younger than 37 years? Give a whole-number, no decimal places.
Q10. If 2,000 children are born each year in Victoria to mothers who will be 37 years or older,
and if the mother's age distribution follows that of the British Columbia study, how many
Down syndrome children would be born to such mothers in one year (in the absence of
prenatal diagnosis and intervention)? Give a whole-number, no decimal places.
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