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1. The MN blood system is inherited as an autosomal trait showing codominance. The genotype LMLM results in the phenotype of M type blood, LMLN results in MN type blood, and LNLN results in type N blood. In a sample of 730 Australian Aboriginal people, 22 had M type blood, 216 had MN blood and 492 had N blood. Calculate the allele and genotype frequencies for this population. Test to see if this population is in Hardy-Weinberg Equilibrium for this locus. If H- W can be rejected propose a hypothesis that would account for the deviation.

1. The MN blood system is inherited as an autosomal trait showing codominance. The genotype LMLM results in the phenotype of M type blood, LMLN results in MN type blood, and LNLN results in type N blood. In a sample of 730 Australian Aboriginal people, 22 had M type blood, 216 had MN blood and 492 had N blood. Calculate the allele and genotype frequencies for this population. Test to see if this population is in Hardy-Weinberg Equilibrium for this locus. If H- W can be rejected propose a hypothesis that would account for the deviation.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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**Title: Understanding the MN Blood System and Hardy-Weinberg Equilibrium** --- **Text:** 1. The MN blood system is inherited as an autosomal trait showing codominance. The genotype \( L^M L^M \) results in the phenotype of M type blood, \( L^M L^N \) results in MN type blood, and \( L^N L^N \) results in type N blood. In a sample of 730 Australian Aboriginal people, 22 had M type blood, 216 had MN blood, and 492 had N blood. Calculate the allele and genotype frequencies for this population. Test to see if this population is in Hardy-Weinberg Equilibrium for this locus. If Hardy-Weinberg equilibrium can be rejected, propose a hypothesis that would account for the deviation. --- **Explanation:** In the study of genetics, the MN blood group system is an example of codominance, where both alleles are equally expressed when present. In this situation, we aim to calculate the allele frequencies of \( L^M \) and \( L^N \) from the given population data: - **Allele Frequencies Calculation:** - \( L^M \) frequency (\( p \)) = frequency of M type blood + half the frequency of MN type blood - \( L^N \) frequency (\( q \)) = frequency of N type blood + half the frequency of MN type blood - **Genotype Frequencies:** - \( L^M L^M \) (M type) - \( L^M L^N \) (MN type) - \( L^N L^N \) (N type) Once the allele frequencies are calculated, we can utilize the Hardy-Weinberg equation to compare expected frequencies with the observed to see if the population is in equilibrium. - **Hardy-Weinberg Equilibrium:** Use the equation \( p^2 + 2pq + q^2 = 1 \) to test for equilibrium: - \( p^2 \) : expected frequency of \( L^M L^M \) - \( 2pq \) : expected frequency of \( L^M L^N \) - \( q^2 \) : expected frequency of \( L^N L^N \) If there is a significant deviation from equilibrium, potential factors such
Transcribed Image Text:**Title: Understanding the MN Blood System and Hardy-Weinberg Equilibrium** --- **Text:** 1. The MN blood system is inherited as an autosomal trait showing codominance. The genotype \( L^M L^M \) results in the phenotype of M type blood, \( L^M L^N \) results in MN type blood, and \( L^N L^N \) results in type N blood. In a sample of 730 Australian Aboriginal people, 22 had M type blood, 216 had MN blood, and 492 had N blood. Calculate the allele and genotype frequencies for this population. Test to see if this population is in Hardy-Weinberg Equilibrium for this locus. If Hardy-Weinberg equilibrium can be rejected, propose a hypothesis that would account for the deviation. --- **Explanation:** In the study of genetics, the MN blood group system is an example of codominance, where both alleles are equally expressed when present. In this situation, we aim to calculate the allele frequencies of \( L^M \) and \( L^N \) from the given population data: - **Allele Frequencies Calculation:** - \( L^M \) frequency (\( p \)) = frequency of M type blood + half the frequency of MN type blood - \( L^N \) frequency (\( q \)) = frequency of N type blood + half the frequency of MN type blood - **Genotype Frequencies:** - \( L^M L^M \) (M type) - \( L^M L^N \) (MN type) - \( L^N L^N \) (N type) Once the allele frequencies are calculated, we can utilize the Hardy-Weinberg equation to compare expected frequencies with the observed to see if the population is in equilibrium. - **Hardy-Weinberg Equilibrium:** Use the equation \( p^2 + 2pq + q^2 = 1 \) to test for equilibrium: - \( p^2 \) : expected frequency of \( L^M L^M \) - \( 2pq \) : expected frequency of \( L^M L^N \) - \( q^2 \) : expected frequency of \( L^N L^N \) If there is a significant deviation from equilibrium, potential factors such
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