Cytotoxic T cells express which of the following proteins on their cell surface? (Select all that apply) а. T cell receptor (TCR) b. CD8 С. CD4 d. B cell receptor
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A:
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- Why HIV doesn’t naturally induce a strong CD8+ T cell response? (Select all that apply if more than one option is correct.) a. The virus is not recognized by BCRs b. HIV antigens cannot be presented on MHC II c. HIV antigens cannot be presented on MHC I d. HIV does not readily infect non-T cells e. HIV cannot interact with CD8 2. Explain the previous question by select all the correct following options. How are CD8+ T cell responses against HIV induced? HIV antigens need to be ______. a. presented to CD8 T cells by B cells b. cross-presented c. presented to CD8 T cells by unnifected DCs d. delivered as a vaccinemay destroy infected cells. Select one: a. Phagocytic cells b. Natural killer T cells C. Cytotoxic T cells O d. Helper T cellsWhich of the following is NOT a involved in the CD8-T-cell killing of viral-infected cells? Select one: a. Recognition of the MHC Class I and viral-derived peptide on the surface of the target cell Ob. Reorientation of the intracellular cytoskeleton to move the cytotoxic granules toward the SMAC c. Release of perforin and granzymes onto the infected target cell Od. Induction of apoptosis in the target cell by cleaving the nuclear DNA. e. Costimulation of CD8-T-cells with CD28/B7
- CD1-restricted α:β T cells respond to lipid antigens of mycobacterial pathogens using all except which of the following? a. CD1a b. CD1b c. CD1c d. CD1d.All of the following are characteristic of regulatory T cells except a. they express CD25 b. they facilitate the proliferation of naive T cells interacting with the same antigen-presenting cell c. they express CD4 d. they express the transcriptional repressor FoxP3 e. they express MHC class II-restricted T-cell receptors specific for self antigen.When endogenous antigens "blend in"( i.e establish a presence on the cell membrane) between the Major Histocompatibility Complex Antigens, this signals a. Everything is normal b. Plasma cells will form c. A phagoctye unable to ingest more antigens. d. Helper T cell will secrete interleukin-2 e. A cell has been infected
- Helper T cells can be activated by macrophages(which engulf everything indiscriminately) or by B cells (which only engulf antigens that stick to their receptors). A. What properties so macrophages and B cells have ibn common that allows them both to activate T cells? B. It has been suggested that macrophages probably do most to fhte T cell activating in the primary response but B cells do most of it in the secondary response. Why does this make sense?What does the T-cell receptor on the helper T cell bind? free antigen in soluble form b. antigens presented with MHC I molecules haptens only. d. antigens presented with MHC II molecules C.Which ONE of the following is necessary after chimeric antigen receptor (CAR)‐T cell therapy for relapsed acute lymphoblastic leukaemia? Select one: A.2 years of maintenance mercaptopurine B.2 years of maintenance mercaptopurine C.Prophylactic antifungal therapy D.Lifelong immunoglobulin replacement therapy
- The detrimental effects of Lupus erythematosis are initiated by A. activated T cells attacking myelin B. immune complexes lodging in capillaries C. lack of activated CD4+ cells1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and ivWhich of the following is not used as a treatment for autoimmune diseases? Select one: A. Anti-IL2 receptor B. Anti-CD4 C. Anti-MHC D. Anti-CCR5 E. Anti-T cell receptor