Cyclic peptides received increasing amounts of attention because of their pharmaceutical propertie including interruption of protein-protein interactions. Please provide a mechanism for the synthesis of the cyclic peptide below from a prodrug protected linear peptide. (Amino acid R groups are simplified to A2, A3, ... as they are not participating in the reaction).

Q: For each of the coupling steps, you will add 4 times excess of the amino acid and 4 times excess of…

A: The solution is given in the following steps:

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Q: Which of the amines shown could, in principle, be used as a resolving agent for a racemic carboxylic…

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Q: Drew the structure of the first non-peptide product released upon trifuoroscetic acid treatment in…

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Q: b) A student attempted the resolution of racemic a-phenylethylamine using the tartaric acid…

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Q: Which of the following would provide a synthesis of leucine? (CH3)2C=CHCH₂OH, HBr/peroxides,…

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Q: 1. The following homopolymers & a. polyhistidine pH 8 b. poly glutamate acid pH 2 C. poly aspirgine…

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Q: Why does the first reaction, but not the second, give ring expansion?

A: In case of β-aminoalcohol, the N2 group leaves from the primary centre, resulting in the ring…

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Q: Suggest methods for the synthesis of the compounds shown below, starting from the appropriate…

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Q: Propose a mechanism for the synthesis of a polycarbazole using Yamamoto coupling. Apply details.

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Q: both of them. Which C=0 will vibrate at higher frequency and why?

A: Ester and amide both possess C=O moeity, one vibrate near to 1735 cm-1 and other vibrate near to…

Q: consider a mixture of the following molecules glycine, 2-aminoethan-1-olate, ethanamine, ethanolate.…

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Q: QUESTION 3 Below is a proposed method for resolving a racemic mixture of (R)- and (S)-phenylalanine.…

A: The objective of the question is to predict the product of the given reaction.

Q: Which of the following would provide a synthesis of leucine? (CH3)2C=CHCH₂OH, HBr/peroxides,…

A:

Q: Assuming the target is composite of hydrophobic, aromatic and basic amino acids residues. Give this…

A: Amino acids are the building blocks of protein. There are various kind of amino acids like…

Q: What is the structure of the active electrophile formed in a peptide coupling mediated by…

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Q: (1) Give the names of the two amino acids used to form the dipeptide shown below. Cy, N=c=N Ph Ph…

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Q: As shown a proposed mechanism for carboxypeptidase A.(a) What is the role of Glu 270 in…

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Q: 1. еxcess CH, 2. Ag,0 (aq.) I HN 3. heat ?

A: In the Hofmann elimination reaction, the least substituted alkene is formed from quaternary ammonium…

Q: ii) - Ozonides to Ozonides are kept at low temp while working What does that requirement prevent…

A: Answer:As we know,Reaction is spontaneous when  is less than zero.

Q: Thoroughly explain why (a)malthose is a reducing sugar while trehalose is not based on their…

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A: ORGANIC REACTION MECHANISM CAN'T BE EXPLAIN PROPERLY IN TYPED,SO TO EXPLAIN PROPERLY WE NEED THE…

Q: We saw that primary amines react with aldehydes and ketones to form imines. Secondary amines (NHRR’)…

A: primary amines react with aldehydes and ketones to form imines.Secondary amines, NHRR', do not…

Q: Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and…

A: The carboxylic acid functional group is represented by R-COOH, where R can be an alkyl or aryl…

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Q: What will you do to detect the presence of protein in powdered casein?  Briefly explain each…

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Coordination Chemistry

It is a part of chemistry, in which the study of compounds that have central atoms surrounded by molecules or ions, known as ligand, is known as coordination chemistry.