Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by-products using electronic and structural effects. The arrow push mechanism must be shows. (from the reaction of α-ketoacids and oxaprolines to proteins that contain native serine residues)
Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by-products using electronic and structural effects. The arrow push mechanism must be shows. (from the reaction of α-ketoacids and oxaprolines to proteins that contain native serine residues)
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by-products using electronic and structural effects. The arrow push mechanism must be shows. (from the reaction of α-ketoacids and oxaprolines to proteins that contain native serine residues)
Transcribed Image Text:5-oxaproline
(Opr)
1,2-oxazetidine
(Ozt)
10-15 mM
R1
R1
R2
HO,
R2
40 - 60 °C
oxalic acid
OH
a-ketoacid
Opr
Homo-serine
KAHA ligation
100 uM - 5 mM
R1
R1
R3
HO.
R3
20 - 25 °C
HO,
lower concentration
Serine
a-ketoacid
Özt
lower temperature
no additives
R1, R2 R3 = amino acid residues
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