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QUESTIONS The structure of cocaine is shown below. The following analogues were synthesised and tested. From these results identify the 2D pharmacophore for cocaine and suggest binding roles for each pharmacophore group. Decreased activity No effect on activity Decreased activity Decreased activity PADAY OF SCENCE QUESTIONS Using the cocaine pharmacophore you have just described, draw structures of some possible simplified cocaine analogues that should retain activity.

QUESTIONS The structure of cocaine is shown below. The following analogues were synthesised and tested. From these results identify the 2D pharmacophore for cocaine and suggest binding roles for each pharmacophore group. Decreased activity No effect on activity Decreased activity Decreased activity PADAY OF SCENCE QUESTIONS Using the cocaine pharmacophore you have just described, draw structures of some possible simplified cocaine analogues that should retain activity.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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QUESTIONS The structure of cocaine is shown below. The following analogues were synthesised and tested. From these results identify the 2D pharmacophore for cocaine and suggest binding roles for each pharmacophore group. Decreased activity No effect on activity Decreased activity Decreased activity PADATY OF SCENCE QUESTIONS Using the cocaine pharmacophore you have just described, draw structures of some possible simplified cocaine analogues that should retain activity.
Transcribed Image Text:QUESTIONS The structure of cocaine is shown below. The following analogues were synthesised and tested. From these results identify the 2D pharmacophore for cocaine and suggest binding roles for each pharmacophore group. Decreased activity No effect on activity Decreased activity Decreased activity PADATY OF SCENCE QUESTIONS Using the cocaine pharmacophore you have just described, draw structures of some possible simplified cocaine analogues that should retain activity.
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