QUESTIONS The structure of cocaine is shown below. The following analogues were synthesised and tested. From these results identify the 2D pharmacophore for cocaine and suggest binding roles for each pharmacophore group. Decreased activity No effect on activity Decreased activity Decreased activity PADAY OF SCENCE QUESTIONS Using the cocaine pharmacophore you have just described, draw structures of some possible simplified cocaine analogues that should retain activity.

QUESTIONS The structure of cocaine is shown below. The following analogues were synthesised and tested. From these results identify the 2D pharmacophore for cocaine and suggest binding roles for each pharmacophore group. Decreased activity No effect on activity Decreased activity Decreased activity PADAY OF SCENCE QUESTIONS Using the cocaine pharmacophore you have just described, draw structures of some possible simplified cocaine analogues that should retain activity.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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