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Consider the following original coding sequence of a gene that codes for a short 5- amino acid polypeptide: 5'-ATGGGCTCGAACTCATAA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? First base in codon U C A G U Phe (F) UUU UUC- UUA UUG CUU- CCU CUC CCC CUA CCA CUG- CCG AUU ACU AUC lle (1) ACC AUA- ACA AUG Met (M) start ACG GUU- GCU GUC GCC GUA GCA GUG GCG Leu (L) Leu (L) Second base Val (V) UCU UCC UCA UCG C Ser (S) Pro (P) Thr (T) Ala (A) codon UAU UAC UAA UAG- GAU- GAC- GAA GAG A Tyr (Y) CAU CAC CAAT CAG- AAU AAC AAA AAG STOP His (H) Gln (Q) Asn (N) Lys (K) Asp (D) Glu (E) G UGU UGC UGA STOP UGG Trp (W) CGU CGC CGA CGG AGU AGC AGA AGG GGU GGC GGA GGG Cys (C) Arg (R) Ser (S) Arg (R) Gly (G) U C A G U C A داواolcاد G U C A G U C A G Last base in codon

Consider the following original coding sequence of a gene that codes for a short 5- amino acid polypeptide: 5'-ATGGGCTCGAACTCATAA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? First base in codon U C A G U Phe (F) UUU UUC- UUA UUG CUU- CCU CUC CCC CUA CCA CUG- CCG AUU ACU AUC lle (1) ACC AUA- ACA AUG Met (M) start ACG GUU- GCU GUC GCC GUA GCA GUG GCG Leu (L) Leu (L) Second base Val (V) UCU UCC UCA UCG C Ser (S) Pro (P) Thr (T) Ala (A) codon UAU UAC UAA UAG- GAU- GAC- GAA GAG A Tyr (Y) CAU CAC CAAT CAG- AAU AAC AAA AAG STOP His (H) Gln (Q) Asn (N) Lys (K) Asp (D) Glu (E) G UGU UGC UGA STOP UGG Trp (W) CGU CGC CGA CGG AGU AGC AGA AGG GGU GGC GGA GGG Cys (C) Arg (R) Ser (S) Arg (R) Gly (G) U C A G U C A داواolcاد G U C A G U C A G Last base in codon

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Consider the following original coding sequence of a gene that codes for a short 5- amino acid polypeptide: 5'-ATGGGCTCGAACTCATAA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? First base in codon U U A UUU UUC- UUA UUG- CUU CUC CUA CUG- U Phe (F) Leu (L) Leu (L) Second base in codon Val (V) UCU - UCC UCA UCG CCU CCC CCA CCG AUU ACU- AUC Ile (1) ACC AUA- ACA AUG Met (M) start ACG GUU GCU- GUC GCC GUA GCA GUG GCG- C Ser (S) Pro (P) Thr (T) Ala (A) UAU UAC UAAT UAG CAU CAC CAA CAG AAU AAC AAA AAG GAU GAC GAA GAG A Tyr (Y) STOP His (H) Gln (Q) Asn (N) Lys (K) Asp (D) Glu (E) G UGU UGC UGA STOP UGG Trp (W) Cys (C) CGU CGC CGA CGG AGU AGC AGA 1 AGG GGU- GGC GGA GGG Arg (R) Ser (S) Arg (R) Gly (G) U C A G U C A G U C A G U C A G Last base in codon
Transcribed Image Text:Consider the following original coding sequence of a gene that codes for a short 5- amino acid polypeptide: 5'-ATGGGCTCGAACTCATAA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? First base in codon U U A UUU UUC- UUA UUG- CUU CUC CUA CUG- U Phe (F) Leu (L) Leu (L) Second base in codon Val (V) UCU - UCC UCA UCG CCU CCC CCA CCG AUU ACU- AUC Ile (1) ACC AUA- ACA AUG Met (M) start ACG GUU GCU- GUC GCC GUA GCA GUG GCG- C Ser (S) Pro (P) Thr (T) Ala (A) UAU UAC UAAT UAG CAU CAC CAA CAG AAU AAC AAA AAG GAU GAC GAA GAG A Tyr (Y) STOP His (H) Gln (Q) Asn (N) Lys (K) Asp (D) Glu (E) G UGU UGC UGA STOP UGG Trp (W) Cys (C) CGU CGC CGA CGG AGU AGC AGA 1 AGG GGU- GGC GGA GGG Arg (R) Ser (S) Arg (R) Gly (G) U C A G U C A G U C A G U C A G Last base in codon
Side chain (R group) H H₂N+ C T H -C-0 Glycine (Gly or G) O CH₂ S CH₂ CH₂ H₂N+ C C-O H Methionine (Met or M) Serine (Ser or S) OH CH₂ H₂N-C- -C- O HO Polar side chains; hydrophilic O O CH₂2₂ H₂N+ C CH3 H₂N-C-C-0- но Alanine (Ala or A) OH CH3 CH H₂N+ C -C -0 I H O H O Aspartic acid (Asp or D) Threonine (Thr or T) Electrically charged side chains; hydrophilic CH₂ H₂N+ C-C Acidic (negatively charged) -0- H O Phenylalanine (Phe or F) H₂N+ C O CH₂ CH₂ H₂N+ C T H -0- H O Glutamic acid (Glu or E) 0 SH CH₂ H₂N+ C -C -0 I H O O Cysteine (Cys or C) CH3 CH3 CH Valine (Val or V) NH₂+ CH₂ CH₂2 CH₂ CH₂ H₂N-C- || O H Lysine (Lys or K) CH₂ H₂N+ C-C | H O Tyrosine (Tyr or Y) CH3 CH3 CH CH₂2 H₂N-C-C-0 | || HO OH CH₂ H₂N-C-C-0 NH HO Tryptophan (Trp or W) Leucine (Leu or L) 0 -0- H₂N-C NH, O CH₂ H₂N-C Basic (positively charged) NH₂ CNH, NH CH₂ CH₂ CH₂ HO Asparagine (Asn or N) O I H Arginine (Arg or R) -C-0- H₂C H₂N+ CH₂ CH₂ H₂C-CH H₂N-C CH₂ H O Isoleucine (lle or I) CH₂ с H O Proline (Pro or P) 0 H₂N+ -NH+ -NH с -0 U=O 0 NH₂ ‚_—_—_—_—_—_J_ T H 0 CH₂ H₂N-C-C-0- H Histidine (His or H) Glutamine (Gln or Q) O -0
Transcribed Image Text:Side chain (R group) H H₂N+ C T H -C-0 Glycine (Gly or G) O CH₂ S CH₂ CH₂ H₂N+ C C-O H Methionine (Met or M) Serine (Ser or S) OH CH₂ H₂N-C- -C- O HO Polar side chains; hydrophilic O O CH₂2₂ H₂N+ C CH3 H₂N-C-C-0- но Alanine (Ala or A) OH CH3 CH H₂N+ C -C -0 I H O H O Aspartic acid (Asp or D) Threonine (Thr or T) Electrically charged side chains; hydrophilic CH₂ H₂N+ C-C Acidic (negatively charged) -0- H O Phenylalanine (Phe or F) H₂N+ C O CH₂ CH₂ H₂N+ C T H -0- H O Glutamic acid (Glu or E) 0 SH CH₂ H₂N+ C -C -0 I H O O Cysteine (Cys or C) CH3 CH3 CH Valine (Val or V) NH₂+ CH₂ CH₂2 CH₂ CH₂ H₂N-C- || O H Lysine (Lys or K) CH₂ H₂N+ C-C | H O Tyrosine (Tyr or Y) CH3 CH3 CH CH₂2 H₂N-C-C-0 | || HO OH CH₂ H₂N-C-C-0 NH HO Tryptophan (Trp or W) Leucine (Leu or L) 0 -0- H₂N-C NH, O CH₂ H₂N-C Basic (positively charged) NH₂ CNH, NH CH₂ CH₂ CH₂ HO Asparagine (Asn or N) O I H Arginine (Arg or R) -C-0- H₂C H₂N+ CH₂ CH₂ H₂C-CH H₂N-C CH₂ H O Isoleucine (lle or I) CH₂ с H O Proline (Pro or P) 0 H₂N+ -NH+ -NH с -0 U=O 0 NH₂ ‚_—_—_—_—_—_J_ T H 0 CH₂ H₂N-C-C-0- H Histidine (His or H) Glutamine (Gln or Q) O -0
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Follow-up Question
 

a) 

5'-ATGGGCTCGCACTCATAA-3'
 

b) 

5'-ATGGTCTCGAACTCATAA-3'
 

c) 

5'-ATGGGCTCGAACTCATAA-3'
 

d) 

5'-ATGGGCTCGAACACATAA-3'
 

e) 

5'-ATGGGCTCGAATTCATAA-3'

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