Consider the data below to answer the following questions. Cyanohydrins are important intermediates in the synthesis of a-hydroxycarboxylic acids from ketones and aldehydes. The nitrile functional group can be hydrolyzed by aqueous acid to yield a carboxylic acid. Nitriles can also be hydrolyzed to carboxylic acids using aqueous base. Unfortunately, when a cyanohydrin is treated with aqueous base the original carbonyl compound is isolated. HO H HCEN H-3- HO' NaOH HO cyanohychin a. a nucleophilic substitution b. an electrophilic addition C10 OH CH-COOH A. The reaction of an aldehyde with hydrogen cyanide is an example of + NaCN + H₂O reaction. H- C. an electrophilic substitution d. a nucleophilic addition B. Identify the electrophile in the reaction of benzaldehyde with hydrogen cyanide.
Consider the data below to answer the following questions. Cyanohydrins are important intermediates in the synthesis of a-hydroxycarboxylic acids from ketones and aldehydes. The nitrile functional group can be hydrolyzed by aqueous acid to yield a carboxylic acid. Nitriles can also be hydrolyzed to carboxylic acids using aqueous base. Unfortunately, when a cyanohydrin is treated with aqueous base the original carbonyl compound is isolated. HO H HCEN H-3- HO' NaOH HO cyanohychin a. a nucleophilic substitution b. an electrophilic addition C10 OH CH-COOH A. The reaction of an aldehyde with hydrogen cyanide is an example of + NaCN + H₂O reaction. H- C. an electrophilic substitution d. a nucleophilic addition B. Identify the electrophile in the reaction of benzaldehyde with hydrogen cyanide.
Chemistry for Today: General, Organic, and Biochemistry
9th Edition
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Chapter16: Amines And Amides
Section: Chapter Questions
Problem 16.54E
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Transcribed Image Text:Consider the data below to answer the following questions.
Cyanohydrins are important intermediates in the synthesis of a-hydroxycarboxylic acids from ketones
and aldehydes. The nitrile functional group can be hydrolyzed by aqueous acid to yield a carboxylic
acid. Nitriles can also be hydrolyzed to carboxylic acids using aqueous base. Unfortunately, when a
cyanohydrin is treated with aqueous base the original carbonyl compound is isolated.
HO
H
HCEN
H-3-
HO'
NaOH
HO
cyanohychin
a.
a nucleophilic substitution
b.
an electrophilic addition
C10
OH
CH-COOH
A. The reaction of an aldehyde with hydrogen cyanide is an example of
+ NaCN + H₂O
reaction.
H-
C.
an electrophilic substitution
d. a nucleophilic addition
B. Identify the electrophile in the reaction of benzaldehyde with hydrogen cyanide.
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