Consider Dr. Whitt’s comments about the relationship between the wild-type and mutant RB1 alleles and what you now know about Knudson’s two-hit hypothesis. Do these ideas seem to confirm or contradict your earlier prediction (based on the pedigree) about whether the mutant RB1 allele is dominant or recessive to the wild-type allele? Explain TりG2M.F IIG3TVJulieG4G1 :1- Julie's matern al GrandmotheyGt : 2 - Julie's Gra nd fathenJulie's unde->Julie'smotherJulie's fatherG3- Julie'shus bandJuleisyourgorbrotherJeulieTVJulie'solder 6rotherkay "But," interjected Chris, “shouldn't I have given her a normal copy of this gene? So, she should be fine, shouldn't she?""Yes," replied Dr. Whitt, “Kay has a normal-functioning, or 'wild-type,' copy of the RB1 gene, which she probably gotfrom you, Chris. In her other body cells, this copy is still intact and protecting those cells from becoming cancerous.However, likely during development, one of the retinal cells in her eye suffered a second mutation. Or, maybe that celllost the second copy of the gene by some mechanism other that mutation. Either way, the normal copy of the RB1gene was lost in that cell and all the cells it gave rise to. The mutated cells lost their ability to regulate their growth.Retinoblastoma was virtually inevitable after that. This is a very important gene.'

Name: Consider Dr. Whitt’s comments about the relationship between the wild-
Uploaded: 2024-03-20T06:43:04.000Z
Channel: Bartleby
Description: Consider Dr. Whitt’s comments about the relationship between the wild-type and mutant RB1 alleles and what you now know about Knudson’s two-hit hypothesis. Do these ideas seem to confirm or contradict your earlier prediction (based on the pedigree) a