Canavan disease in an autosomal recessive disorder caused by mutations in the gene that codes for the enzyme aspartoacylase resulting in incomplete synthesis of myelin sheaths. Individuals affected by Canavan disease experience lack of motor development, abnormal muscle tone, and difficulty feeding. Most individuals affected by this disease die before the age of 10.  In a particular population in Canada, researchers examined 250 people for Canavan disease and found that 45 of them had the disorder.   a) What is the frequency of Canavan disease in the population examined by the researchers?  Show all your work. Express your answer as a value between 0 and 1 rounded to two decimal places. b) What is the frequency of the Canavan disease carriers in the population examined by the researchers? Show all your work. Express your answer as a value between 0 and 1 rounded to two decimal places.

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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Canavan Disease 

Canavan disease in an autosomal recessive disorder caused by mutations in the gene that codes for the enzyme aspartoacylase resulting in incomplete synthesis of myelin sheaths. Individuals affected by Canavan disease experience lack of motor development, abnormal muscle tone, and difficulty feeding. Most individuals affected by this disease die before the age of 10. 

In a particular population in Canada, researchers examined 250 people for Canavan disease and found that 45 of them had the disorder.  

a) What is the frequency of Canavan disease in the population examined by the researchers? 

Show all your work. Express your answer as a value between 0 and 1 rounded to two decimal places.

b) What is the frequency of the Canavan disease carriers in the population examined by the researchers?

Show all your work. Express your answer as a value between 0 and 1 rounded to two decimal places. 

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