Canavan Disease Canavan disease is an autosomal recessive disorder caused by mutations in the gene that codes for the enzyme aspartoacylase, resulting in an incomplete synthesis of myelin sheaths. Individuals affected by Canavan disease experience a lack of motor development, abnormal muscle tone, and difficulty feeding. Most individuals affected by this disease die before age 10. In a particular population in Canada, researchers examined 1850 people for Canavan disease and found that 10 of them had the disorder. 1. What is the frequency of Canavan disease in the population examined by the researchers? (1 mark) 2. How many individuals are unaffected carriers of the disease? (2 marks) Show all your work.
Canavan Disease Canavan disease is an autosomal recessive disorder caused by mutations in the gene that codes for the enzyme aspartoacylase, resulting in an incomplete synthesis of myelin sheaths. Individuals affected by Canavan disease experience a lack of motor development, abnormal muscle tone, and difficulty feeding. Most individuals affected by this disease die before age 10. In a particular population in Canada, researchers examined 1850 people for Canavan disease and found that 10 of them had the disorder. 1. What is the frequency of Canavan disease in the population examined by the researchers? (1 mark) 2. How many individuals are unaffected carriers of the disease? (2 marks) Show all your work.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
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Transcribed Image Text:Canavan Disease
Canavan disease is an autosomal recessive disorder caused by mutations in the gene that codes for the enzyme aspartoacylase, resulting in
an incomplete synthesis of myelin sheaths. Individuals affected by Canavan disease experience a lack of motor development, abnormal
muscle tone, and difficulty feeding. Most individuals affected by this disease die before age 10.
In a particular population in Canada, researchers examined 1850 people for Canavan disease and found that 10 of them had the disorder.
1. What is the frequency of Canavan disease in the population examined by the researchers? (1 mark)
2. How many individuals are unaffected carriers of the disease? (2 marks)
Show all your work.
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