Calculate and compare the AG' values for the oxidation of succinate by NAD and FAD. Use the data given in the table to find the E' of the NAD: NADH and fumarate:succinate couples, and assume that E for the enzyme-bound FAD : FADH₂ redox + Couple is nearly +0.05 V. Oxidant NAD+ Fumarate Reductant NADH + H Succinate AGO for the oxidation of succinate by NAD: AGO' for the oxidation of succinate by FAD: n 2 2 E'o (V) -0.32 -0.03 + Why is FAD rather than NAD the electron acceptor in the reaction catalyzed by succinate dehydrogenase? kJ mol-¹ kJ mol-¹

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Calculate and compare the AGº' values for the oxidation of succinate by NAD and FAD. Use the data given in the table to find
the E' of the NAD: NADH and fumarate:succinate couples, and assume that E' for the enzyme-bound FAD : FADH₂ redox
+
couple is nearly +0.05 V.
Oxidant
NAD
+
Fumarate
Reductant
NADH + H
Succinate
+
AGO for the oxidation of succinate by NAD
AGO for the oxidation of succinate by FAD:
n
2
E'o (V)
-0.32
T
-0.03
+
FAD is an oxidant, whereas NAD is a reductant.
+
Why is FAD rather than NAD the electron acceptor in the reaction catalyzed by succinate dehydrogenase?
+
The oxidation of succinate by NAD is not thermodynamically feasible.
+
The oxidation of succinate requires two NAD molecules but only one FAD molecule.
+
The electron-transport chain can regenerate FAD, but not NAD˚.
kJ mol-¹
-1
kJ mol-¹
Transcribed Image Text:Calculate and compare the AGº' values for the oxidation of succinate by NAD and FAD. Use the data given in the table to find the E' of the NAD: NADH and fumarate:succinate couples, and assume that E' for the enzyme-bound FAD : FADH₂ redox + couple is nearly +0.05 V. Oxidant NAD + Fumarate Reductant NADH + H Succinate + AGO for the oxidation of succinate by NAD AGO for the oxidation of succinate by FAD: n 2 E'o (V) -0.32 T -0.03 + FAD is an oxidant, whereas NAD is a reductant. + Why is FAD rather than NAD the electron acceptor in the reaction catalyzed by succinate dehydrogenase? + The oxidation of succinate by NAD is not thermodynamically feasible. + The oxidation of succinate requires two NAD molecules but only one FAD molecule. + The electron-transport chain can regenerate FAD, but not NAD˚. kJ mol-¹ -1 kJ mol-¹
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