Biolink 'Drugs and their Conformations' (a) Which drug is more likely to produce multiple physiological effects: a drug with conformational flexibility or a drug with a rigid structure? Explain. (b) Using the example of HIV drugs, describe how conformation flexbility helps us keep up with drug resistance.
Biolink 'Drugs and their Conformations' (a) Which drug is more likely to produce multiple physiological effects: a drug with conformational flexibility or a drug with a rigid structure? Explain. (b) Using the example of HIV drugs, describe how conformation flexbility helps us keep up with drug resistance.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
Transcribed Image Text:Biolink 'Drugs and their
Conformations' (a) Which
drug is more likely to produce multiple
physiological effects: a drug with conformational
flexibility or a drug with a rigid structure?
Explain. (b) Using the example of HIV drugs,
describe how conformation flexbility helps us keep
up with drug resistance.
Expert Solution
Step 1 (a)
Drugs and their conformation - drug conformation is the local arrangement of the atoms in a drug molecule. Drugs can be rigid (conformation restriction) and flexible (conformation flexibility) drug molecules. Flexible drug give ensemble of conformational states and rigid drug gives a single conformational state. More the rigidity in the drug structure, lowers the entropy loss during the rigid drug and ligand binding.
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