ATP ADP Phosphoglucomutase Glucose 1-phosphate Fructose .................... Glycogen ATP ADP 6-phosphate PFK-1 Fructose 1,6-biphosphate Glucose Glucose Hexokinase 6-phosphate G6P Isomerase NADP+ NADPH 6-phosphogluconolactone G6P Dehydrogenase Nucleotides

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Glucose 6-phosphate is also a precursor for the synthesis of nucleotides that are used to build DNA and RNA. The first step of this pathway is catalyzed by an enzyme called glucose 6-phosphate dehydrogenase. Assume that reactions in this pathway with double arrows are reversible under cellular conditions, while those with single arrows are effectively irreversible.

Which of the following enzymes, if present in your fructose-6-phosphate solution, would most substantially decrease the amount of 6-phosphogluconolactone you produce?

  1. Phosphoglucomutase
  2. G6P Dehydrogenase
  3. G6P Isomerase
  4. Hexokinase
  5. PFK-1
ATP ADP
Phosphoglucomutase
Glucose
1-phosphate
Fructose
.................... Glycogen
ATP ADP
6-phosphate PFK-1
Fructose
1,6-biphosphate
Glucose
Glucose
Hexokinase 6-phosphate
G6P Isomerase
NADP+
NADPH
6-phosphogluconolactone
G6P Dehydrogenase
Nucleotides
Transcribed Image Text:ATP ADP Phosphoglucomutase Glucose 1-phosphate Fructose .................... Glycogen ATP ADP 6-phosphate PFK-1 Fructose 1,6-biphosphate Glucose Glucose Hexokinase 6-phosphate G6P Isomerase NADP+ NADPH 6-phosphogluconolactone G6P Dehydrogenase Nucleotides
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