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Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Remember that hexose kinase is an enzyme required for hexose metabolism, a process that takes a
6-carbon sugar and breaks it down into 2 pyruvate molecules.
You discover that rather than being hormonally regulated (as seen above in humans), hexose kinase
is part of an operon in prokaryotic organisms. This operon is known as the "hexose operon" and it
regulates expression of the complete set of enzymes needed to convert a hexose sugar into 2
pyruvate molecules.
Like the lac operon, the hexose operon is controlled by a separate regulatory protein under the control
of its own promoter (see the schematic of the operon below). The hexose regulatory protein is
sensitive to fatty acyl CoA levels. When all hexose fuel sources are depleted, the bacteria switch to
lipid metabolism and fatty acyl CoA levels increase. This turns expression of the hexose operon off.
+1
+1
Regulatory Gene
Pregulator
Poperon
Hexose Operon Genes
regulator promoter
operon promoter
Question 5
F) Complete the diagrams below to reflect the proteins and any relevant cofactors (e.g. -
inducer/repressor molecules) that you would expect to be occupying this operon's regulatory
region in the presence of low vs high fatty acyl CoA levels.
↑ [hexose], [fatty acyl CoA] = negligible
[hexose] = negligible, T[ fatty acyl COA]
%3D
promoter
operator
Transcribed Image Text:Remember that hexose kinase is an enzyme required for hexose metabolism, a process that takes a 6-carbon sugar and breaks it down into 2 pyruvate molecules. You discover that rather than being hormonally regulated (as seen above in humans), hexose kinase is part of an operon in prokaryotic organisms. This operon is known as the "hexose operon" and it regulates expression of the complete set of enzymes needed to convert a hexose sugar into 2 pyruvate molecules. Like the lac operon, the hexose operon is controlled by a separate regulatory protein under the control of its own promoter (see the schematic of the operon below). The hexose regulatory protein is sensitive to fatty acyl CoA levels. When all hexose fuel sources are depleted, the bacteria switch to lipid metabolism and fatty acyl CoA levels increase. This turns expression of the hexose operon off. +1 +1 Regulatory Gene Pregulator Poperon Hexose Operon Genes regulator promoter operon promoter Question 5 F) Complete the diagrams below to reflect the proteins and any relevant cofactors (e.g. - inducer/repressor molecules) that you would expect to be occupying this operon's regulatory region in the presence of low vs high fatty acyl CoA levels. ↑ [hexose], [fatty acyl CoA] = negligible [hexose] = negligible, T[ fatty acyl COA] %3D promoter operator
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