Alpha thalassemia is a hereditary blood condition that results in varying levels of anemia. It is tied to the HB alpha 1 gene and the HB alpha 2 gene on human chromosome 16. The diagram shows the proteins for the hemoglobin genes and the pedigree shows genotypes, designated by the letter X, on the chromosomes for a family affected by the condition. Which represents the predicted level of anemia in a child born to the mother and father in the image with a mutation that results in a genotype of xxxx? Why? A - mild anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin B - severe anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin C - mild anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin D - severe anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Alpha thalassemia is a hereditary blood condition that results in varying levels of anemia. It is tied to the HB alpha 1 gene and the HB alpha 2 gene on human chromosome 16.

The diagram shows the proteins for the hemoglobin genes and the pedigree shows genotypes, designated by the letter X, on the chromosomes for a family affected by the condition.

Which represents the predicted level of anemia in a child born to the mother and father in the image with a mutation that results in a genotype of xxxx? Why?

A - mild anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin


B - severe anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin


C - mild anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin


D - severe anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin

Alpha Globin
Genes
a1
а2
a4
a3
Hemoglobin Protein
Chromosome 16
Key
Father
Mother
Silent carrier
(no signs
of anemia)
Thalassemia
Chromosome 16
(2 alpha-globin
genes from
each parent * 4)
trait
(mild anemia)
Child
Child
Hemoglobin
H disease
(moderate to
severe anemia)
Child
Does not
have anemia
Child
Thalassemia
trait
Silent carrier
(no signs
of anemia)
(mild anemia)
Transcribed Image Text:Alpha Globin Genes a1 а2 a4 a3 Hemoglobin Protein Chromosome 16 Key Father Mother Silent carrier (no signs of anemia) Thalassemia Chromosome 16 (2 alpha-globin genes from each parent * 4) trait (mild anemia) Child Child Hemoglobin H disease (moderate to severe anemia) Child Does not have anemia Child Thalassemia trait Silent carrier (no signs of anemia) (mild anemia)
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