alpha-amanitin is an extremely deadly toxin produced by death cap mushrooms. It specifically blocks the activity of RNA polymerase II, but not other RNA polymerases. Based on what we've learned in class so far, what's the most likely molecular mechanism leading to fatality when a human eats a death cap mushroom? Group of answer choices Failure to transcribe rRNA Failure of sigma factor to bind to promoter Failure to replicate DNA Failure to transcribe pre-mRNA Failure to transcribe tRNA Failure to translate polypeptides

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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alpha-amanitin is an extremely deadly toxin produced by death cap mushrooms. It specifically blocks the activity of RNA polymerase II, but not other RNA polymerases. Based on what we've learned in class so far, what's the most likely molecular mechanism leading to fatality when a human eats a death cap mushroom? Group of answer choices Failure to transcribe rRNA Failure of sigma factor to bind to promoter Failure to replicate DNA Failure to transcribe pre-mRNA Failure to transcribe tRNA Failure to translate polypeptides
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Step 1: Introduction:

Alpha amamitin is a toxin produced from Amanita phalloides, a death cap mushroom. This species of mushroom contains a white stem, greenish cap, and white gills. These species are mostly found in pine, oak, and other woodlands of Europe and North America. These species release alpha-amanitin that inhibits the activity of RNA polymerase Ii, thus inhibiting transcription.

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