Mismatch repair corrects replicative errors 3 -GÁTC CTAG 3' GATC 5 - CTAG- Muts recognizes mismatched pair. Muts 3' -GÁTC- CTAG 3 GATC -CTAG 5' 3' MutH recognizes methylated parent strand and nicks daughter strand. Mutl MutH 5 3 GÁTC CTAG 3' GATC CTAG 5' 3' New strand is excised and replaced between nick and mismatched pair. 3 GÁTC. СТАG 3' GATÇ - CTAG 5' G .C FIGURE 16-23 Model for mismatch repair in E. col. DNA is methylated (Me) at the A residue in the sequence GATC. DNA repication yields a hemimethylated duplex that exists until methylase can modify the newly synthesized strand. The mismatch- repair system makes any necessary corrections based on the sequence found on the methylated strand (original template). MutS, MutH, and Mut. are proteins. d between the n human mis- nly the newly exing in organ- and C. elegans. gnition of free strands. peat sequences in n io

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question

The MutH protein nicks the newly synthesized strand
(Figure 16-23). How does it “know” which strand this is?

Mismatch repair corrects
replicative errors
3
-GÁTC
CTAG
3'
GATC
5
- CTAG-
Muts recognizes
mismatched pair.
Muts
3'
-GÁTC-
CTAG
3
GATC
-CTAG
5'
3'
MutH recognizes
methylated parent
strand and nicks
daughter strand.
Mutl
MutH
5
3
GÁTC
CTAG
3'
GATC
CTAG
5'
3'
New strand is excised
and replaced between
nick and mismatched pair.
3
GÁTC.
СТАG
3'
GATÇ
- CTAG
5'
G
.C
FIGURE 16-23 Model for mismatch repair
in E. col. DNA is methylated (Me) at the
A residue in the sequence GATC. DNA
repication yields a hemimethylated duplex
that exists until methylase can modify the
newly synthesized strand. The mismatch-
repair system makes any necessary
corrections based on the sequence found
on the methylated strand (original template).
MutS, MutH, and Mut. are proteins.
d between the
n human mis-
nly the newly
exing in organ-
and C. elegans.
gnition of free
strands.
peat sequences
in n
io
Transcribed Image Text:Mismatch repair corrects replicative errors 3 -GÁTC CTAG 3' GATC 5 - CTAG- Muts recognizes mismatched pair. Muts 3' -GÁTC- CTAG 3 GATC -CTAG 5' 3' MutH recognizes methylated parent strand and nicks daughter strand. Mutl MutH 5 3 GÁTC CTAG 3' GATC CTAG 5' 3' New strand is excised and replaced between nick and mismatched pair. 3 GÁTC. СТАG 3' GATÇ - CTAG 5' G .C FIGURE 16-23 Model for mismatch repair in E. col. DNA is methylated (Me) at the A residue in the sequence GATC. DNA repication yields a hemimethylated duplex that exists until methylase can modify the newly synthesized strand. The mismatch- repair system makes any necessary corrections based on the sequence found on the methylated strand (original template). MutS, MutH, and Mut. are proteins. d between the n human mis- nly the newly exing in organ- and C. elegans. gnition of free strands. peat sequences in n io
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