Aldol reactions provide another way to build longer or branched carbon chains. Write a retro- synthetic reaction plan for preparation of this compound using a base-catalyzed aldol reaction or condensation. What base should be used to generate the enolate required for this reaction? Is the enolate a kinetic enolate or a thermodynamic enolate? محدد OH . Using the starting material for synthesis of the compound shown above, another aldol product is possible. Write the reaction to show formation of the other possible product. Assume base catalysis.
Aldol reactions provide another way to build longer or branched carbon chains. Write a retro- synthetic reaction plan for preparation of this compound using a base-catalyzed aldol reaction or condensation. What base should be used to generate the enolate required for this reaction? Is the enolate a kinetic enolate or a thermodynamic enolate? محدد OH . Using the starting material for synthesis of the compound shown above, another aldol product is possible. Write the reaction to show formation of the other possible product. Assume base catalysis.
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
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![### Aldol Reactions and Enolate Formation
**Aldol reactions provide another way to build longer or branched carbon chains.**
#### Retro-Synthetic Analysis
You are tasked with writing a retro-synthetic reaction plan for the preparation of the given compound using a base-catalyzed aldol reaction or condensation.
**Key Questions to Consider:**
- What base should be used to generate the enolate required for this reaction?
- Is the enolate a *kinetic enolate* or a *thermodynamic enolate*?
#### Reaction Pathway
The image shows a series of chemical structures indicating the step-wise transformation leading to the desired aldol product:
1. The initial reactant is a carbonyl compound that leads to an enolate ion formation.
2. The enolate reacts with a second carbonyl-containing molecule.
3. An aldol product is formed, featuring a new carbon-carbon bond and a hydroxyl group (OH).
#### Exercise
Using the starting material for the synthesis of the compound shown:
- **Create another aldol product:** This involves using the given structure and reorienting the reaction pathway to yield an alternative product.
- **Base Catalysis Assumption:** The reactions should assume the presence of a base catalyst to facilitate enolate ion formation.
This exercise helps illustrate the flexibility and utility of aldol reactions in synthetic organic chemistry, allowing for the creation of complex molecular architectures from simple precursors.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fe25ab048-dae6-46db-830a-1de98cbaaebf%2F634f5520-4a30-4d58-8444-2d1401b97d0c%2F52tp1zd_processed.png&w=3840&q=75)
Transcribed Image Text:### Aldol Reactions and Enolate Formation
**Aldol reactions provide another way to build longer or branched carbon chains.**
#### Retro-Synthetic Analysis
You are tasked with writing a retro-synthetic reaction plan for the preparation of the given compound using a base-catalyzed aldol reaction or condensation.
**Key Questions to Consider:**
- What base should be used to generate the enolate required for this reaction?
- Is the enolate a *kinetic enolate* or a *thermodynamic enolate*?
#### Reaction Pathway
The image shows a series of chemical structures indicating the step-wise transformation leading to the desired aldol product:
1. The initial reactant is a carbonyl compound that leads to an enolate ion formation.
2. The enolate reacts with a second carbonyl-containing molecule.
3. An aldol product is formed, featuring a new carbon-carbon bond and a hydroxyl group (OH).
#### Exercise
Using the starting material for the synthesis of the compound shown:
- **Create another aldol product:** This involves using the given structure and reorienting the reaction pathway to yield an alternative product.
- **Base Catalysis Assumption:** The reactions should assume the presence of a base catalyst to facilitate enolate ion formation.
This exercise helps illustrate the flexibility and utility of aldol reactions in synthetic organic chemistry, allowing for the creation of complex molecular architectures from simple precursors.
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