Consider the following reaction. What is the role of LDA?CH2CH3CHCO Et1. LDA, THF2. CH3CH₂BrCHCO₂EtLDA acts as a nucleophile and is substituted by the THF.LDA acts as a base and removes a proton from the alpha carbon to form theenolate.LDA acts as an electrophile and adds to the alkyl halide so it is easier tosubstitute.LDA acts as an acid to protonate the carbonyl carbon to form a goodelectrophile.

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Answered: Consider the following reaction. What…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter23: Addition To A Carbonyl

Section: Chapter Questions

Problem 41CTQ

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2. Identify the nucleophile and electrophile in the given reaction. Show the electron rich and the electron deficient sites in the substrates. Et20 CI Nucleophile: Electrophile:
1. NaOEt CO₂Et 2. H3O+ 3. heat Br H3C CO₂H CO2 H3C CO₂Et The malonic ester synthesis is a carbonyl alkylation reaction. It is used to prepare carboxylic acids from primary alkyl halides, lengthening the carbon chain by two atoms. Thus, the product can be visualized as being a "substituted acetic acid." The reaction consists of three steps: generation of the enolate anion followed by SN2 reaction with a primary alkyl halide, ester hydrolysis under acid conditions, and decarboxylation. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions 22 CX EtO₂C EtO₂C HOCH2CH3 HOCH2CH3 EtO₂C EtO₂C
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4 5 6
Write the mechanism step by step and completely starting from the reagent to the formation of the product 1) LDA 2) H;O, A 2 H 1) NAOH 2) Н.О. Д
A bacteria produces an aromatic product starting with the enolate shown below.Step 1. An aldol condensation reaction.Step 2. Two keto-enol tautomerization.Step 3. Ester hydrolysis followed by decarboxylation Draw the structure of the final product with formula C11H16O2.
A bacteria produces an aromatic product starting with the enolate shown below. Step 1. An aldol condensation reaction. Step 2. Two keto-enol tautomerizations. Step 3. Ester hydrolysis followed by decarboxylation. Draw the structure of the final product with formula C11H16O2.
1. NaOEt CO₂Et 2. H3O+ 3. heat Br H3C H₁C CO₂Et CO₂H CO2 + EtOH The malonic ester synthesis is a carbonyl alkylation reaction. It is used to prepare carboxylic acids from primary alkyl halides, lengthening the carbon chain by two atoms. Thus, the product can be visualized as being a "substituted acetic acid." The reaction consists of three steps: generation of the enolate anion followed by SN2 reaction with a primary alkyl halide, ester hydrolysis under acid conditions, and decarboxylation. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions EtO₂C X ¯:0: :0: Br: EtO₂C. Br CH3 H3C CH3 CH3 56
HCI is a byproduct of this reaction. Which statements are true? CH₂ . Cl₂ HCI prevents CH3 from acting as a leaving group HCI ensures that only one H of the CH3 is substituted by lowering the pH CH₂CI HCI can accelerate the reaction as it forms by catalyzing keto-enol tautomerism HCI can slow the reaction by enabling the formation of an enolate + HCI
What is the product of the following reaction sequence? 1) NaOEt (excess) H,0, H* 1) SOCI, EtO 2) 2 CH,CH,Br heat 2) NH, OEt `NH2 `NH2 `NH2 NH2 В. C. D. A. O A O'B O D MacBook Pro G Search or type URL #3 & * $ E T Y D F G H K * CO
Place the intermediates in the correct order to complete the mechanism for the following reaction. Reaction: HO H. но, HO H. OH HO. H.
Which reaction (s) does an anhydride produce? HO. NEl3 CI КОН I. calor OK II NH2 O. IV HO HO. calor III a. Ob., IV Oc. I, II d., II, III, IV

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