ACTIVITY 10.6.1 Label the diagram and explain the salient feature that is happening in each item. For the complexes and the mobile carriers, kindly give their alternative names Electron Transport Chain Intermembrane space Inner mitochondrial membrane Intermembrane space H* 7 6. Mitochondrial matrix 4. 1 2e- FADH2 NADH FAD 2H + 1/202 H20 NAD" + ATP ADP Mitochondrial matrix Inner mitochondrial membrane P, Name of the Transporter Essential Features 1. 2. 6. 7. 3. 4. 5.

ACTIVITY 10.6.1 Label the diagram and explain the salient feature that is happening in each item. For the complexes and the mobile carriers, kindly give their alternative names Electron Transport Chain Intermembrane space Inner mitochondrial membrane Intermembrane space H* 7 6. Mitochondrial matrix 4. 1 2e- FADH2 NADH FAD 2H + 1/202 H20 NAD" + ATP ADP Mitochondrial matrix Inner mitochondrial membrane P, Name of the Transporter Essential Features 1. 2. 6. 7. 3. 4. 5.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter27: Metabolic Integration And Organ Specialization

Section: Chapter Questions

Problem 2P

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Based on the image below select the correct statements Intermembrane space Inner mitochondrial membrane NADH NAD+ Proton pump ATP synthase ADP + P₁ verifier-SGorLXZ61a39Ecjya7yr5Yf3404XUmXKRi3wHy13 ATP Mitochondrial matrix https://canvas.uts.edu.au/assessment questions/356921/files/1562662/download?
Additional information: ATP production by the ETC and ATP Synthase per glucose varies somewhat depending on the energy required to move NADH into the mitochondria and other energy uses for the hydrogen-ion gradient. Additional questions: 1.) How many ATP's are generally yielded by oxidative phosphorylation from the catabolism of one glucose? 2.) Summarize the total ATP's obtained from a single molecule of glucose, from start to finish? asap
Examsoft E mitochondria Question #: 25 X concentration of acetylcholine had no effect on enzyme inhibition. Further, analysis of the mixture indicted that no While developing new inhibitors we came up with new compound, a derivative of acetylcholine (neurotransfer) This new neurotransmitter showed inhibition of the enzyme A in presence of acetylcholine. In addition, increase in additional products or intermediate were formed or seen. Based on this information this inhibitor is; A. Competitive inhibitor B. Non-competitive Inhibitor C. Covalent Inhibitor D. None of the above
ACTIVITY 10.6.2 Provide what is being asked. 1. A patient has an inborn mutation causing the inability to produce succinate dehydrogenase required for the oxidation of FADH2. Will this person still produce ATP? Explain your answer. 2 Mutations in the genes that encode certain mitochondrial proteins are associated with a high incidence of some type of cancer. How might defective mitochondria lead to cancer? 3. How is cytochrome c related to apoptosis? 4. Fill in the table below Pathway Number of ATP produced from one glucose molecule Number of H carriers produced from one glucose molecule NADH FADH2 Glycolysis Krebs Cycle Electron Transport Chain Total ATP Produced
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Rationalize why 4 (and not 5 or 10) protons are transferred from inside to outside of the mitochondrial inner membrane by the Complex I? (Hint: use redox potential of NADH and Ubiquinone, mitochondrial membrane pH =0.75 units, and the potential difference across the inner mitochondrial membrane = 0.15V) For the purpose of energy utilization, what are the advantages of generating energy from lipids as compared to that of carbohydrates? Justify by chemical reason.
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Recall that beta-hydroxybutyrate is oxidized by the enzyme beta-hydroxybutyrate dehydrogenase withsimultaneous reduction of NAD+ to NADH. How might this affect the reduction potential at Complex I in theelectron transport chain? (Note: you will need to use the form of the Nernst equation that uses non-standardconditions.)
Calculate the delta G of proton transport through the mitochondrial inner membrane. Is this a spontaneous or nonspontaneous process?
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Rat heart muscle operating aerobically fills more than 90% of its ATP needs by oxidative phosphorylation. If each gram of tissue consumes O2 at the rate of 12.0 micromol/min, with glucose as the fuel source. (a) Calculate the rate at which the heart muscle consumes glucose and produces ATP. (b) Consider an alternate scenario – what would be the rate of consumption if the energy source was a solely triglycerides whose fatty acyl chains were each 14-C in length and saturated? (Assume the O2 consumption rate remains at 12.0 micromol/min) (c) For a steady-state concentration of ATP of 6.0 micromol/g of heart muscle tissue, calculate the time required (in seconds) to completely turn over the cellular pool of ATP if glucose us used as the sole fuel source. What does this result indicate about the need for tight regulation of ATP production? (Note: Concentrations are expressed as micromoles per gram of muscle tissue because the tissue is mostly water.)