In experiments carried out in 1941 to investigate the citric acid cycle, oxaloacetate labeled with ¹4C in the carboxyl carbon atom farthest from the keto group was introduced to an active preparation of mitochondria. COO CH₂ COO™ Oxaloacetate Analysis of the a-ketoglutarate formed showed that none of the radioactive label had been lost. Decarboxylation of x-ketoglutarate then yielded succinate devoid of radioactivity. All the label was in the released CO₂. Use an asterisk (*) to indicate the location of ¹4C in the intermediates and products of the pathway that converts [¹4C] oxaloacetate into succinate.
In experiments carried out in 1941 to investigate the citric acid cycle, oxaloacetate labeled with ¹4C in the carboxyl carbon atom farthest from the keto group was introduced to an active preparation of mitochondria. COO CH₂ COO™ Oxaloacetate Analysis of the a-ketoglutarate formed showed that none of the radioactive label had been lost. Decarboxylation of x-ketoglutarate then yielded succinate devoid of radioactivity. All the label was in the released CO₂. Use an asterisk (*) to indicate the location of ¹4C in the intermediates and products of the pathway that converts [¹4C] oxaloacetate into succinate.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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![COO
OOD
CH₂
14 COO
[14C]Oxaloacetate
-COO™
CH₂
0 CH₂
-COO
OOC
D
*
COO
-CH₂
-C- -OH
CH₂
COO
Citrate
COO
-CH₂
-CH₂
=0
S-COA
CO₂
-CH₂
-COO
OOC-CH
0 HC
0
C
-OH
Isocitrate
Kdo₂
COO
-CH₂
CH₂
=O
-COO™](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F55e357e2-ac09-4338-9465-57b99a722707%2Fb6736d3d-dec2-4a4d-b869-8fc39388e270%2For54wek_processed.png&w=3840&q=75)
Transcribed Image Text:COO
OOD
CH₂
14 COO
[14C]Oxaloacetate
-COO™
CH₂
0 CH₂
-COO
OOC
D
*
COO
-CH₂
-C- -OH
CH₂
COO
Citrate
COO
-CH₂
-CH₂
=0
S-COA
CO₂
-CH₂
-COO
OOC-CH
0 HC
0
C
-OH
Isocitrate
Kdo₂
COO
-CH₂
CH₂
=O
-COO™
![In experiments carried out in 1941 to investigate the citric acid cycle, oxaloacetate labeled with ¹4C in the carboxyl carbon atom
farthest from the keto group was introduced to an active preparation of mitochondria.
COO™
CH₂
COO™
Oxaloacetate
Analysis of the a-ketoglutarate formed showed that none of the radioactive label had been lost. Decarboxylation of
a-ketoglutarate then yielded succinate devoid of radioactivity. All the label was in the released CO₂.
Use an asterisk (*) to indicate the location of ¹4℃ in the intermediates and products of the pathway that converts
[¹4C] oxaloacetate into succinate.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F55e357e2-ac09-4338-9465-57b99a722707%2Fb6736d3d-dec2-4a4d-b869-8fc39388e270%2Fp3zppc_processed.png&w=3840&q=75)
Transcribed Image Text:In experiments carried out in 1941 to investigate the citric acid cycle, oxaloacetate labeled with ¹4C in the carboxyl carbon atom
farthest from the keto group was introduced to an active preparation of mitochondria.
COO™
CH₂
COO™
Oxaloacetate
Analysis of the a-ketoglutarate formed showed that none of the radioactive label had been lost. Decarboxylation of
a-ketoglutarate then yielded succinate devoid of radioactivity. All the label was in the released CO₂.
Use an asterisk (*) to indicate the location of ¹4℃ in the intermediates and products of the pathway that converts
[¹4C] oxaloacetate into succinate.
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