2. Energetics of the electron transport. In the oxidative phase of oxidative phosphorylation, electrons are passed from NADH and ultimately to molecular oxygen through an electron transport chain comprised of multiple redox centers. Assume that an electron is passed through the chain along the route shown below. Clearly, there are steps missing, but we will skip those to emphasize the energetics of the electron transport. Calculate DEº' and DGo' for each electron transfer step and record the values in the table. The reduction potentials for each of the redox centers are given in table 11.1. (F=96.4 kJ/V mol) Route: NADH → (Fe-S)N-5,6 → Coenzyme Q → Cytochrome c₁ → Cytochrome a3 → 0₂

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Chapter1: Biochemistry: An Evolving Science
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Solve for Delta DEo’ and  nFDEo’= DGo’

2. Energetics of the electron transport. In the oxidative phase of oxidative phosphorylation, electrons are passed
from NADH and ultimately to molecular oxygen through an electron transport chain comprised of multiple
redox centers. Assume that an electron is passed through the chain along the route shown below. Clearly, there
are steps missing, but we will skip those to emphasize the energetics of the electron transport. Calculate DEº'
and DGº' for each electron transfer step and record the values in the table. The reduction potentials for each of
the redox centers are given in table 11.1. (F=96.4 kJ/V mol)
Route:
NADH → (Fe-S)N-5,6 → Coenzyme Q → Cytochrome c₁ → Cytochrome a3 → 0₂
Table 11.1 STANDARD REDUCTION POTENTIALS (E°') FOR SELECTED
ELECTRON CARRIERS IN THE ELECTRON TRANSPORT SYSTEM
Electron carriers
NAD + H+ + 2e → NADH
Complex I (NADH-ubiquinone oxidoreductase)
Fe-S (N-1b)
Fe-S (N-3,4)
Fe-S (N-5,6)
Complex II (succinate dehydrogenase)
FAD + 2H+ + 2e →FADH₂ (enzyme bound)
Fe-S (S-1)
Cytochrome b560
Coenzyme Q + 2 H+ + 2e¯
Complex III (ubiquinone-cytochrome c oxidoreductase)
Cytochrome b
Cytochrome b
Fe-S
Cytochrome c₁
Cytochrome c (Cyt c)
Complex IV (cytochrome c oxidase)
Cytochrome a
CUA
Cytochrome az
O₂ + 2H+ + 2e → H₂O
E° (V)
-0.32
-0.25
-0.24
-0.27
-0.04
-0.03
-0.08
+0.04
+0.03
-0.03
+0.28
+0.21
+0.23
+0.21
+0.24
+0.38
+0.82
Direction of e flow
e transferred from to
NADH (Fe-S)N-5,6
(Fe-S)N-5,6 Coenzyme Q
Coenzyme Q → Cytochrome c₁
Cytochrome c₁ → Cytochrome a3
Cytochrome a3 → 0₂
AE⁰¹
-nFAE⁰¹=
AG⁰¹
Transcribed Image Text:2. Energetics of the electron transport. In the oxidative phase of oxidative phosphorylation, electrons are passed from NADH and ultimately to molecular oxygen through an electron transport chain comprised of multiple redox centers. Assume that an electron is passed through the chain along the route shown below. Clearly, there are steps missing, but we will skip those to emphasize the energetics of the electron transport. Calculate DEº' and DGº' for each electron transfer step and record the values in the table. The reduction potentials for each of the redox centers are given in table 11.1. (F=96.4 kJ/V mol) Route: NADH → (Fe-S)N-5,6 → Coenzyme Q → Cytochrome c₁ → Cytochrome a3 → 0₂ Table 11.1 STANDARD REDUCTION POTENTIALS (E°') FOR SELECTED ELECTRON CARRIERS IN THE ELECTRON TRANSPORT SYSTEM Electron carriers NAD + H+ + 2e → NADH Complex I (NADH-ubiquinone oxidoreductase) Fe-S (N-1b) Fe-S (N-3,4) Fe-S (N-5,6) Complex II (succinate dehydrogenase) FAD + 2H+ + 2e →FADH₂ (enzyme bound) Fe-S (S-1) Cytochrome b560 Coenzyme Q + 2 H+ + 2e¯ Complex III (ubiquinone-cytochrome c oxidoreductase) Cytochrome b Cytochrome b Fe-S Cytochrome c₁ Cytochrome c (Cyt c) Complex IV (cytochrome c oxidase) Cytochrome a CUA Cytochrome az O₂ + 2H+ + 2e → H₂O E° (V) -0.32 -0.25 -0.24 -0.27 -0.04 -0.03 -0.08 +0.04 +0.03 -0.03 +0.28 +0.21 +0.23 +0.21 +0.24 +0.38 +0.82 Direction of e flow e transferred from to NADH (Fe-S)N-5,6 (Fe-S)N-5,6 Coenzyme Q Coenzyme Q → Cytochrome c₁ Cytochrome c₁ → Cytochrome a3 Cytochrome a3 → 0₂ AE⁰¹ -nFAE⁰¹= AG⁰¹
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