Acephate has an oral LD50 of 300mg/kg in rats and of 10mg/kg in roaches. Malathion has an oral LD50 of 0.04g/kg in rats and of 0.01g/kg in roaches. Given that rats serve as good animal models to predict toxicity in humans, which insecticide is predicted to be more toxic to humans, acephate or malathion? Explain Which insecticide is more toxic to roaches, acephate or malathion? Explain

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Substance Abuse

Substance abuse refers to the use of illegal drugs in excessive quantities, as well as the misuse of legal substances such as prescription or over-the-counter pharmaceuticals or alcohol for purposes other than those intended. Drug addiction, also known as substance use disorder, is a disease that affects the brain and behavior of a person. It leads to a failure to control the use of any drug or prescription, legal or illegal.