An athlete tested positive for Methylhexaneamine in urine with a level of 0.90 µg/mL. At her appeal in the Court of Arbitration, she quotes a highly respected scientific publication that states that at levels of 1.0 µg/mL there is no performance enhancement. If the athlete’s levels are indeed below this threshold, the athlete can face a year’s suspension instead of a ban for life. Use the Estimate of Uncertainty to determine if the Athlete should be given a 1 year suspension or banned for life.
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An athlete tested positive for Methylhexaneamine in urine with a level of 0.90 µg/mL. At her appeal in the Court of Arbitration, she quotes a highly respected scientific publication that states that at levels of 1.0 µg/mL there is no performance enhancement. If the athlete’s levels are indeed below this threshold, the athlete can face a year’s suspension instead of a ban for life. Use the Estimate of Uncertainty to determine if the Athlete should be given a 1 year suspension or banned for life.
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- rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1The loading dose of indomethacin in neonates is 0.2 mg/kg of body weight by intravenous infusion. a. What would be the dose for a neonate weighing 6 lb 4 oz? b. How many milliliters of an injection containing 1 mg of indomethacin per 0.5 mL should be administered to obtain this dose?You're neutering an 85 g sugar glider and need to calculate out how 1 mg/mL meloxicam (NSAID) you need to inject subcutaneously for a final dose 0.2 mg/kg. Do not round your answers. How much meloxicam (in mg) is needed to achieve a final dose of 0.2 mg/kg meloxicam in an 85g sugar glider? Answer mg Volume of 1 mg/mL meloxicam (in cc) needed Answer cc. Is this volume injectable with a 1 cc syringe? AnswerNOYESCANNOT DETERMINE How would you dilute the 1 mg/mL meloxicam solution to make it injectable with a 1 cc syringe?Answer1:101:251:1001:500 What is the new concentration of the meloxicam solution? Answer mg/mL What is the new volume that you would inject in cc? Answer cc
- Assume that Ali (same patient in question 1) was prescribed vancomycin 1000 mg every 36 hours. After few days, Steady-state vancomycin concentrations were obtained before and after the fourth dose, and the peak concentration (obtained ½ hour after a 1- hour infusion of vancomycin) was 34 µg/mL while the trough concentration (obtained immediately before dosage administration) was 2.5 pg/mL. Compute a revised vancomycin dose for this patient to provide a steady-state peak concentration of 48 ug/mL and a steady- state trough concentration of 17 pg/mL. a. Estimate new rate constant (Ke) and half-life (t1/2) b. Estimate volume of distribution (Vd) using this equation Cmaxss + Cminss C. Calculate the new dose interval d. Calculate the new doseThe dose level of Drug XYZ is 60 mg/m2 (Hint: Use the table found in p.19 for the conversion factors)a. What is the dose in body weight (mg/kg) basis in dogs?b. What is the dose in body weight (mg/kg) basis in rats?c. What is the dose in body weight (mg/kg) basis in monkeys?d. What is the dose in body weight (mg/kg) basis in humans? Reference:Guidance for IndustryEstimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers the picture attached to my question is page 19 on my pdfWhen the drug theophylline is administered for asthma, a concentration below 5 mg/L has little effect and undesirable side-effects appear if the concentration exceeds 20 mg/L. For a body that weighs W kg, the concentration when M mg is present is 2M/W mg/L and the constant that measures the rapidity at which the concentration falls is T = 6 h. If a 500-mg tablet of the drug is taken by a person weighing 70 kg, after how many hours should the second dose be taken so as to prevent the drug from falling below the effective concentration? About 6 hours Once a day About 12 hours O About 8 hours
- Azithromycin can be administered either orally as a slow release of active ingredients (known as extended release) or intravenously (IV) into the bloodstream (known as immediate release). Calculate the appropriate dosage of both extended and immediate release azithromycin for a 17.0 lb patient. Orally administered extended-release azithromycin dosage for a child is 60 mg per kg of body weight. Calculate the dosage in mg of azithromycin for a 17.0 lb child. IV administered immediate-release azithromycin dosage for a child is 10 mg per kg of body weight. Calculate the dosage in mg of azithromycin for a 17.0 lb child.Based on the analytical characteristics discussed, explain why the TSH result is reported this way (TSH ≤ 0.3 mU/L). Please answer if you, don't guess or put random answers, I'll put a thumbs down if the answer is not compliant with the questionaccording to the following: the absorbance of the blank sample was 0.07, the absorbance of the standard sample was 0.8, the absorbance of the sample was 0.9 and the concentration of the standard sample was90mg/dl, what is the correct diagnostic regarding the glucose level in this condition, if this sample was taken after fasting for at least 8 hours? a. normal O b. pre-diabetic OC. O c. hyperglycemic O d. diabetic
- Calculate the oral loading dose (LD) of digoxin for Miss Jones who weighs 60 kg. The desired plasma concentration (Cp) is 1.5 mcg/L, volume of distribution (Vd) is 7.3 L/kg, the salt factor (S) is 1 and bioavailability fraction (F) is 0.7.Give your answer to the nearest whole number of micrograms.The equation below can be used:Loading Dose = Cp desired x VdS x FFrom the following data, find the % (w/w) cream of tartar (KHC4H406, MM=188): Wt of sample = 1.4160 g NaOH titrant used = 20.87 mL HCI used for back titration = 1.27 mL 1.00 mL HCI 1.12 mL NaOH 1.00 mL HCI A 0.01930 g CaCO3 89.08% (w/w) 87.12% (w/w) O 47.75% (w/w) O 95.59% (W/w)An 84 year old male patient has been given a loading dose of digoxin of 298 micrograms in divided doses by intravenous infusion. He has a creatinine clearance (Ccr) of 34 ml / min. What is the maintenance dose (in micrograms) that this patient should receive? Round your answer to the nearest whole number. Use the formula provided to calculate the maintenance dose. Maintenance Dose = Peak body stores x % daily loss 100 Where: Peak Body Stores = Loading Dose % Daily Loss = 14 + Creatinine clearance (Ccr) 5