According to your class results, how well does TAS2R38 genotype predict PTC-tasting phenotype? What does this tell you about classical dominant/recessive inheritance?
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- Consider the following pedigree. 하 3 10 (5 3 2 (a) What pattern of transmission is most consistent with this pedigree? (1) autosomal recessive, (2) autosomal dominant, (3) X-linked recessive, (4) X-linked dominant. (b) If individual V-2 marries a normal individual, and if the condition has a pene-trance of 85 percent, what is the probability that their second child will express the trait? (c) On the third line, what does the diamond with a 10 in the middle mean?In a woman who is a carrier of a mutant OTC deficiency allele, her sons who receive the mutant allele will be affected and her daughters will be carriers who may or may not be symptomatic, depending on random X inactivation in the liver. 1) Is this a single gene inheritance or multifactorial disease? 2) Is there a strong genetic or environmental cause to the development of this disease? If both genetic and environmental causes are implicated, you have to indicate each of them separately.What feature(s) of this pedigree indicate(s) dominant inheritance?
- Regarding Mendelian inheritance in diploid individuals, (Read each statement carefully. Select all of the statements below that are true (that you agree with). Leave any statements that are false (that you do not agree with) un- selected.) a diploid individual receives two copies of every autosome from the previous generation. for every autosomal gene inherited by an individual, both copies can come from one parent. a diploid individual gives two copies of every autosome to a child in the next generation. to be diploid means that two independent genes are specified in the individual's genotype.Individuals, such as Ryan Clark and Geno Atkins, heterozygous for the sickle cell allele show effects of the allele under some circumstances (refer to the linked article and Mendelian patterns of inheritance in your text). Explain in terms of gene expression. http://www.nfl.com/news/story/0ap3000000714754/article/coleman-unsure-on-denver-game-due-to-sickle-cell-traitProvide a proof that a different phenotype can be produced from the same genotype. What are the possible causes for this different expression? How can the different gene interactions be differentiated from each other and from the Mendelian inheritance?
- What genetic criteria distinguish a case of extranuclear inheritance from (a) a case of Mendelian autosomal inheritance; (b) a case of X-linked inheritance?The following pedigree illustrates the inheritance of ringed hair, a condition in which each hair is differentiated into light and dark zones. What mode or modes of inheritance are possible for the ringed-hair trait in this family?What feature(s) of this pedigree indicate(s) X-linked recessive inheritance?
- When examining a human pedigree, what features do you look forto distinguish between X-linked recessive inheritance and autosomal recessive inheritance? How would you distinguish X-linkeddominant inheritance from autosomal dominant inheritance in ahuman pedigree?. BRCA1 is a bi-allelic gene (let's call the two alleles as C and c) that is inherited on an autosome. The C allele is completely dominant over c, expressing breast cancer as a phenotype. Eye color is determined by two independently assorting bi-allelic genes, B (alleles B and b) and G (alleles G and g), such that the Ballele shows dominant epistasis over the G and g alleles. Brown-eyed individuals have at least one copy of the B allele, green eyed individuals have at least one G allele, while blue eyed individuals have neither B nor G. A blue-eyed person whą is a heterozygote carrier for the BRCA1 gene has 3 children with a brown-eyed person (heterozygote for both B and G genes) who does not have breast cancer. (a) What are the possible genotypes and phenotypes of all their possible children? What are their respective probabilities of being observed (please write all genotype and phenotype probabilities)? (b) What is the probability that all three children will be blue-eyed and not…Your internship with Dr. Nefario at Gru Industries is going well so far, but a recent mission to obtain a shrink ray requires a special kind of Minion. You identify that the ideal Minion phenotypes for this mission are two eyes, pale yellow, and short. From your previous work, you’ve found that:Two-eyed (D) is completely dominant over one-eyed (d)Yellow (Y) is incompletely dominant with white (y)Tall (T) is completely dominant over short (t) a. The only reproductive individuals you have at the moment (it was surprise mission!) are a true breeding two-eyed, yellow, short Minion and a one heterozygous for each trait. What genotypic ratios would you expect for this crossassuming that each locus is on a different chromosome? What total proportion would you expect to be the desired phenotype for the mission? b. The mission has since been delayed due to lack of financial support, so you’ve got some time. All the individuals from the F1 cross above are now reproductive. Which genotypes would…