A. The team compares the sequence of the gene from the patient with three other patients the team has had with the same symptoms; the mutations for each patient in the table attached. What is the amino acid change in the enzyme from the patient (reference the genetic code)? What amino acid changes are associated with the enzymes from the other three patients? B. How would each of these amino acid changes (from the previous question) would lead to non-functional enzymes?
A. The team compares the sequence of the gene from the patient with three other patients the team has had with the same symptoms; the mutations for each patient in the table attached. What is the amino acid change in the enzyme from the patient (reference the genetic code)? What amino acid changes are associated with the enzymes from the other three patients? B. How would each of these amino acid changes (from the previous question) would lead to non-functional enzymes?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
A team attempts to isolate the gene coding for a defective enzyme. The gene sequence is shown in the table attached; the number at the end of the row is the numerical position of the last base in that row, so the 60th position has a “G”.
A. The team compares the sequence of the gene from the patient with three other patients the team has had with the same symptoms; the mutations for each patient in the table attached. What is the amino acid change in the enzyme from the patient (reference the genetic code)? What amino acid changes are associated with the enzymes from the other three patients?
B. How would each of these amino acid changes (from the previous question) would lead to non-functional enzymes?
Transcribed Image Text:Patient
Justin
Patient A
Patient B
Patient C
Base pair location
319
374
1004
1144
Mutation
C→ A
G → A
G → C
C → T
Transcribed Image Text:ATGACCCAGA
TTGGGCGCCT
GGCAAAGGCT CCGCAGTCTC
ACGCCGGAAC CCTGAACAAC
GACGTGGCAC GGGGCCGCCC
GACTGGAAGG CATCGCCGCG
TGCCACCCGA CACGGAGACC
TGACCATGGC GATGCCCCAC
CCCTCAAGTA CGCCTCCAGA GTGTTCCATC GCGTCCGCTG GGCGCCCGAG
CCCTAGGCTA CCGAGAGTAC CACTCAGCAC GCCGGAGCTT GGCAGACATC
CCAGGCCCCT CTACGCCCAG CTTTCTGGCC GAACTTTTCT GCAAGGGGGG GCTGTCGAGG
CTACACGAGC TGCAGGTGCA GGGCGCCGCG CACTTCGGGC CGGTGTGGCT AGCCAGCTTT
GGGACAGTGC GCACCGTGTA CGTGGCTGCC CCTGCACTCG TCGAGGAGCT GCTGCGACAG
GAGGGACCOC GGCCOGAGEG CTGCAGCTTC TCGCCCTGGA CGGAGCACCG CCGCTGCCGC
CAGCGGGCTT GCGGACTGCT CACTGCTGAA GGCGAAGAAT
CTGGCCCCGC TCCTCCTCCG GCCTCAAGCG GCCGCCCGCT
GTAGTCTGCG ACCTTGTGCG GCGTCTGAGG CGCCAGCGGG
GCCCTGGTTC GGGACGTGGC GGGGGAATTT TACAAGTTCG
GTTCTGCTCG GCTCGCGCTT GGGCTGCCTG GAGGCTCAAG
TTCATCCGCG CTGTGGGCTC GGTGTTTGTG TCCACGCTGT
TGGCTGCGCC ACCTTGTGCC TGGGCCCTGG GGCCGCCTCT
TTTGCATTTG CTCAGAGGCA CGTGGAGCGG CGAGAGGCAG
GGACAGCCCG AGAAGGACCT GGAGTCTGGG GCGCACCTGA
GAGTTGCCTG CCCAGTCCAT CCTGGGAAAT GTGACAGAGT
ACGGTGTCCA ACACGCTCTC TTGGGCTCTG TATGAGCTCT
ACAGCACTCC ACTCAGAGAT CACAGCTGCC CTGAGCCCTG
GCCACTGTTC TGTCCCAGCT GCCCCTGCTG AAGGCGGTGG
TACCCTGTGG TACCTGGAAA TTCTCGTGTC CCAGACAAAG
ATTATCCCCA AAAATACGCT GGTCACTCTG TGTCACTATG
CAGTTCCCAG AGCCAAATTC TTTTCGTCCA GCTCGCTGGC
CACCCA
CTTT GGCAAGCGCA
AATTGCAAAT GGCTTTGGCC CAGATCCTAA
CGGCCCCAGT TAGACCCAAG ACCCGGACTG
GCCGAGACTG GGACCAGATG
AGTTTTTGGA CAGATAG
GCAGAGCTTG
GAGCCAGGTG
ATCAACCTAC
CA
TTCC
AGGCAGCCAT GAGGAACGGA
CCCACTTCCT GTTCCGGGAA
TGCTATTGGC GGGAGTGGAC
CCCGGCACCC CGAAGTCCAG
GCTCCAGTGC CTACCCCTCA
TCAAGGAAGT GCTAAGACTG
ACATTCATGT GGGTGACTAT
CCACTTCAAG GGACCCTGCC
TGGGGGAGGG TCCCACCCCC
GGG GAGACGCCTG
CACATTTTGA GGTGCAGCCT
TCCTGGTACC TGAAAGGAGC
GC
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