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a. Describe the process of protein folding and quality control. What are the steps and major proteins involved in folding, quality control, and the outcome if a protein is not properly folded? What is ED

a. Describe the process of protein folding and quality control. What are the steps and major proteins involved in folding, quality control, and the outcome if a protein is not properly folded? What is ED

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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2. You are studying protein folding and quality control. You hypothesize that protein, ERRP, is an ER resident protein that is required for the process of protein folding and quality control. Answer the following questions and then use the answers to help you to design an experiment to test your hypothesis. a. Describe the process of protein folding and quality control. What are the steps and major proteins involved in folding, quality control, and the outcome if a protein is not properly folded? b. What is an ER resident protein? Provide examples of ER resident proteins and explain the cellular mechanism used to localize ER resident proteins to the ER; how do these proteins get to the ER? how do they stay in the ER? How are they sent back to the ER if they accidentally get shipped to the Golgi? c. You decide to mutate the gene that encodes ERRP so that it is localized to the Cytoplasm instead of the ER so you can observe the effects on protein folding and quality control. What kind of mutation would you make that would result in the protein localizing to the cytoplasm? Why would this mutation result in localizing ERRP to the cytoplasm? d. You decide to make a second mutation to localize the protein to the Nucleus rather than the ER. What kind of mutation would result in localization of the protein to the Nucleus? Why would this mutation result in localizing ERRP to the nucleus? е. How can you use these mutants to test your hypothesis? Remember your hypothesis was - ERRP is an ER resident protein that is required for protein folding and quality control.
Transcribed Image Text:2. You are studying protein folding and quality control. You hypothesize that protein, ERRP, is an ER resident protein that is required for the process of protein folding and quality control. Answer the following questions and then use the answers to help you to design an experiment to test your hypothesis. a. Describe the process of protein folding and quality control. What are the steps and major proteins involved in folding, quality control, and the outcome if a protein is not properly folded? b. What is an ER resident protein? Provide examples of ER resident proteins and explain the cellular mechanism used to localize ER resident proteins to the ER; how do these proteins get to the ER? how do they stay in the ER? How are they sent back to the ER if they accidentally get shipped to the Golgi? c. You decide to mutate the gene that encodes ERRP so that it is localized to the Cytoplasm instead of the ER so you can observe the effects on protein folding and quality control. What kind of mutation would you make that would result in the protein localizing to the cytoplasm? Why would this mutation result in localizing ERRP to the cytoplasm? d. You decide to make a second mutation to localize the protein to the Nucleus rather than the ER. What kind of mutation would result in localization of the protein to the Nucleus? Why would this mutation result in localizing ERRP to the nucleus? е. How can you use these mutants to test your hypothesis? Remember your hypothesis was - ERRP is an ER resident protein that is required for protein folding and quality control.
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