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A membrane oxygenator is being designed as part of a heart-lung bypass machine. It must be able to transfer 200 ml/min of O2 into blood flowing at 5 I/min. Assume the blood enters the oxygenator with an effective O, concentration of 0.1 ml O,/ml blood. (a) With what O2 concentration should the blood leave the oxygenator? You can solve this question easily by thinking about an overall mass balance. (b) One design is to make the oxygenator as a “stack" containing many "units", as shown Fig. 7.30. Each unit consists of a channel filled with flowing blood, an O2-filled channel, and flat membranes separating the channels. The membranes are 10 cm x 10 cm by 5 µm thick, and the height of each blood-containing channel is 1 cm. The 02-containing channels are filled with 100% O2, which is equivalent to a blood con- centration of 0.204 ml O2/ml blood. How many membrane units are needed to supply the required oxygen? The value for Deff of Oz in the membranes is measured as 10-6 cm²/s. Membranes Blood One membrane unit Pure oxygen Blood Next membrane unit Pure oxygen Figure 7.30

A membrane oxygenator is being designed as part of a heart-lung bypass machine. It must be able to transfer 200 ml/min of O2 into blood flowing at 5 I/min. Assume the blood enters the oxygenator with an effective O, concentration of 0.1 ml O,/ml blood. (a) With what O2 concentration should the blood leave the oxygenator? You can solve this question easily by thinking about an overall mass balance. (b) One design is to make the oxygenator as a “stack" containing many "units", as shown Fig. 7.30. Each unit consists of a channel filled with flowing blood, an O2-filled channel, and flat membranes separating the channels. The membranes are 10 cm x 10 cm by 5 µm thick, and the height of each blood-containing channel is 1 cm. The 02-containing channels are filled with 100% O2, which is equivalent to a blood con- centration of 0.204 ml O2/ml blood. How many membrane units are needed to supply the required oxygen? The value for Deff of Oz in the membranes is measured as 10-6 cm²/s. Membranes Blood One membrane unit Pure oxygen Blood Next membrane unit Pure oxygen Figure 7.30

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A membrane oxygenator is being designed as part of a heart-lung bypass machine. It must be able to transfer 200 ml/min of O2 into blood flowing at 5 I/min. Assume the blood enters the oxygenator with an effective O, concentration of 0.1 ml O,/ml blood. (a) With what O2 concentration should the blood leave the oxygenator? You can solve this question easily by thinking about an overall mass balance. (b) One design is to make the oxygenator as a “stack" containing many "units", as shown Fig. 7.30. Each unit consists of a channel filled with flowing blood, an O2-filled channel, and flat membranes separating the channels. The membranes are 10 cm x 10 cm by 5 µm thick, and the height of each blood-containing channel is 1 cm. The 02-containing channels are filled with 100% O2, which is equivalent to a blood con- centration of 0.204 ml O2/ml blood. How many membrane units are needed to supply the required oxygen? The value for Deff of Oz in the membranes is measured as 10-6 cm²/s.
Transcribed Image Text:A membrane oxygenator is being designed as part of a heart-lung bypass machine. It must be able to transfer 200 ml/min of O2 into blood flowing at 5 I/min. Assume the blood enters the oxygenator with an effective O, concentration of 0.1 ml O,/ml blood. (a) With what O2 concentration should the blood leave the oxygenator? You can solve this question easily by thinking about an overall mass balance. (b) One design is to make the oxygenator as a “stack" containing many "units", as shown Fig. 7.30. Each unit consists of a channel filled with flowing blood, an O2-filled channel, and flat membranes separating the channels. The membranes are 10 cm x 10 cm by 5 µm thick, and the height of each blood-containing channel is 1 cm. The 02-containing channels are filled with 100% O2, which is equivalent to a blood con- centration of 0.204 ml O2/ml blood. How many membrane units are needed to supply the required oxygen? The value for Deff of Oz in the membranes is measured as 10-6 cm²/s.
Membranes Blood One membrane unit Pure oxygen Blood Next membrane unit Pure oxygen Figure 7.30
Transcribed Image Text:Membranes Blood One membrane unit Pure oxygen Blood Next membrane unit Pure oxygen Figure 7.30
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