One medication used in treating COVID patients who have been placed on mechanical ventilators is Vecuronium, an acetylchone antagonist at skeletal muscle neuromuscular junctions (NMJs). Vecuronium is used on sedated patients to provide skeletal muscle paralysis, which allows the mechanical ventilator to work without the patient’s diaphragm contracting on its own and potentially working against the ventilator. Please do two things: Explain the way in which the NMJ would cause skeletal muscle contraction in the absence of the medication. Start by describing the mechanism of neurotransmitter release in the presynaptic cell and stop when the first crossbridge cycle is complete. Explain the specific way in which the medication impacts the functionality of the NMJ and skeletal muscle contraction. Please make sure to include 1.NT release 2.AP 3.Calcium release/binding 4.Crossbridge cycling 5.Med impact
One medication used in treating COVID patients who have been placed on mechanical ventilators is Vecuronium, an acetylchone antagonist at skeletal muscle neuromuscular junctions (NMJs). Vecuronium is used on sedated patients to provide skeletal muscle paralysis, which allows the mechanical ventilator to work without the patient’s diaphragm contracting on its own and potentially working against the ventilator.
Please do two things:
-
Explain the way in which the NMJ would cause skeletal muscle contraction in the absence of the medication. Start by describing the mechanism of neurotransmitter release in the presynaptic cell and stop when the first crossbridge cycle is complete.
-
Explain the specific way in which the medication impacts the functionality of the NMJ and skeletal muscle contraction.
Please make sure to include
1.NT release
2.AP
3.Calcium release/binding
4.Crossbridge cycling
5.Med impact
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