A patient carrying a mutant form of hemoglobin (KD = 48 torr) is planning to take part in a hiking trip that involves strenuous physical activity at ~10,000 feet above sea level. The mutant hemoglobin has reduced oxygen binding cooperativity (n = 2.2) and displays no major structural abnormalities. a. Calculate the percent saturation of hemoglobin in the lungs (pO2 = 70 torr at this elevation) for this patient and for an individual carrying a normal version of hemoglobin b. Calculate the percent saturation of hemoglobin in active skeletal muscle tissue (pO2 = 15 torr) for this patient and for an individual carrying a normal version of hemoglobin c. Will this patient transport oxygen from the lungs to active muscle tissues more or less efficiently than an individual with a normal version of hemoglobin on this trip? Briefly explain your answer
A patient carrying a mutant form of hemoglobin (KD = 48 torr) is planning to take part in a hiking trip that involves strenuous physical activity at ~10,000 feet above sea level. The mutant hemoglobin has reduced oxygen binding cooperativity (n = 2.2) and displays no major structural abnormalities.
a. Calculate the percent saturation of hemoglobin in the lungs (pO2 = 70 torr at this elevation) for this patient and for an individual carrying a normal version of hemoglobin
b. Calculate the percent saturation of hemoglobin in active skeletal muscle tissue (pO2 = 15 torr) for this patient and for an individual carrying a normal version of hemoglobin
c. Will this patient transport oxygen from the lungs to active muscle tissues more or less efficiently
than an individual with a normal version of hemoglobin on this trip? Briefly explain your answer
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Few question on what did,
How did you calculate the pO2 of the patient as 65?
Additionally for the percent saturation if the patient's Kd is 48 shouldn't the first half of part a be divided by (48+65)? Why is it divided by 58+pO2?
Finally what is meant by oxygen binding cooperativety in the problem?
by Bartleby Expert
