The Bohr effect describes the impact of changes in serum pH and CO2 concentrations on the oxygen dissociation curve of hemoglobin. This effect is physiologically important because it allows the body to adapt to changing conditions and provide enough oxygen to different types of tissues. **Plot the curves of hemoglobin oxygen saturation for patients in conditions of acidosis (serum pH below 7.34) and alkalosis (serum pH higher than 7.45) and compare it to the one in normal conditions. ** **When tissues, such as muscle tissue, are performing large amounts of strenuous activity the increase in metabolic activity produces CO2 as waste. Once in the bloodstream the enzyme carbonic anhydrase speeds up the conversion of CO2 to bicarbonate and protons. How does this affect the release of oxygen to the tissues?** **2,3-bisphosphoglycerate is an allosteric inhibitor of oxygen binding to hemoglobin. Acclimatization to high altitude involves numerous physiological and biochemical changes, including an increase in the concentration of 2,3-bisphosphoglycerate in red blood cells. Explain why the 2,3 bisphosphoglycerate concentration increases at high altitude.**
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The Bohr effect describes the impact of changes in serum pH and CO2 concentrations on the oxygen dissociation curve of hemoglobin. This effect is physiologically important because it allows the body to adapt to changing conditions and provide enough oxygen to different types of tissues.
**Plot the curves of hemoglobin oxygen saturation for patients in conditions of acidosis (serum pH below 7.34) and alkalosis (serum pH higher than 7.45) and compare it to the one in normal conditions. **
**When tissues, such as muscle tissue, are performing large amounts of strenuous activity the increase in
**2,3-bisphosphoglycerate is an allosteric inhibitor of oxygen binding to hemoglobin. Acclimatization to high altitude involves numerous physiological and biochemical changes, including an increase in the concentration of 2,3-bisphosphoglycerate in red blood cells. Explain why the 2,3 bisphosphoglycerate concentration increases at high altitude.**
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