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5. The image below shows the organization of a type IV protein that resides on the ER membrane. The N- and C-termini of the protein are labeled. Boxes 1 and 2 represent membrane-spanning sequences. Non-membrane-spanning regions of the protein are labeled "X," "Y," and "Z." A stretch of positively-charged amino acids immediately precedes box 1 (arrow head). Starting from the solid black lines below (representing the bilayer), sketch what the topology of the protein would look like once fully translocated (the solid black lines represent the ER phospholipid bilayer). Indicate on your drawing the ER lumen, the cytosol and if boxes 1 and 2 are SA and/or STA sequences. Z 1 2

5. The image below shows the organization of a type IV protein that resides on the ER membrane. The N- and C-termini of the protein are labeled. Boxes 1 and 2 represent membrane-spanning sequences. Non-membrane-spanning regions of the protein are labeled "X," "Y," and "Z." A stretch of positively-charged amino acids immediately precedes box 1 (arrow head). Starting from the solid black lines below (representing the bilayer), sketch what the topology of the protein would look like once fully translocated (the solid black lines represent the ER phospholipid bilayer). Indicate on your drawing the ER lumen, the cytosol and if boxes 1 and 2 are SA and/or STA sequences. Z 1 2

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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5. The image below shows the organization of a type IV protein that resides on the ER membrane. The N- and C-termini of the protein are labeled. Boxes 1 and 2 represent membrane-spanning sequences. Non-membrane-spanning regions of the protein are labeled "X," "Y," and "Z." A stretch of positively-charged amino acids immediately precedes box 1 (arrow head). Starting from the solid black lines below (representing the bilayer), sketch what the topology of the protein would look like once fully translocated (the solid black lines represent the ER phospholipid bilayer). Indicate on your drawing the ER lumen, the cytosol and if boxes 1 and 2 are SA and/or STA sequences. Z 1 2
Transcribed Image Text:5. The image below shows the organization of a type IV protein that resides on the ER membrane. The N- and C-termini of the protein are labeled. Boxes 1 and 2 represent membrane-spanning sequences. Non-membrane-spanning regions of the protein are labeled "X," "Y," and "Z." A stretch of positively-charged amino acids immediately precedes box 1 (arrow head). Starting from the solid black lines below (representing the bilayer), sketch what the topology of the protein would look like once fully translocated (the solid black lines represent the ER phospholipid bilayer). Indicate on your drawing the ER lumen, the cytosol and if boxes 1 and 2 are SA and/or STA sequences. Z 1 2
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