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5. A mutation causes a change in the shape of the active site of an enzyme involved in glycolysis. This enzyme is an isomerase (see the diagram below). Because of this mutation, this isomerase can no longer convert DHAP into G3P (or G3P into DHAP). What is the total energetic cost during glycolysis due to this mutation? Explain why. You can express the energetic cost in terms of number of ATP molecules per glucose oxidized. You should only consider the cost in glycolysis and none of the processes that occur after that (such as the pyruvate oxidation, the citric acid cycle or the oxidative phosphorylation). Fructose 6-phosphate CH₂0-P CH₂OH H HO H HO H OH ATP GLYCOLYSIS: Energy Investment Phase ADP Phospho- fructokinase Fructose 1,6-bisphosphate P-OCH, H HO H HO CH₂O-P кон H Aldolase Glyceraldehyde 3-phosphate (G3P) HC-0 CHOH CH₂O-P Isomerase 5 CH₂0-P C-o CH₂OH Dihydroxyacetone phosphate (DHAP) ₁₁

5. A mutation causes a change in the shape of the active site of an enzyme involved in glycolysis. This enzyme is an isomerase (see the diagram below). Because of this mutation, this isomerase can no longer convert DHAP into G3P (or G3P into DHAP). What is the total energetic cost during glycolysis due to this mutation? Explain why. You can express the energetic cost in terms of number of ATP molecules per glucose oxidized. You should only consider the cost in glycolysis and none of the processes that occur after that (such as the pyruvate oxidation, the citric acid cycle or the oxidative phosphorylation). Fructose 6-phosphate CH₂0-P CH₂OH H HO H HO H OH ATP GLYCOLYSIS: Energy Investment Phase ADP Phospho- fructokinase Fructose 1,6-bisphosphate P-OCH, H HO H HO CH₂O-P кон H Aldolase Glyceraldehyde 3-phosphate (G3P) HC-0 CHOH CH₂O-P Isomerase 5 CH₂0-P C-o CH₂OH Dihydroxyacetone phosphate (DHAP) ₁₁

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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5. A mutation causes a change in the shape of the active site of an enzyme involved in glycolysis. This enzyme is an isomerase (see the diagram below). Because of this mutation, this isomerase can no longer convert DHAP into G3P (or G3P into DHAP). What is the total energetic cost during glycolysis due to this mutation? Explain why. You can express the energetic cost in terms of number of ATP molecules per glucose oxidized. You should only consider the cost in glycolysis and none of the processes that occur after that (such as the pyruvate oxidation, the citric acid cycle or the oxidative phosphorylation). Fructose ATP 6-phosphate CH₂0-P CH₂OH H H HO HO H OH GLYCOLYSIS: Energy Investment Phase Fructose 1,6-bisphosphate ADP P-OCH ₂ Phospho- fructokinase 3 H HO H HO H CH₂O-P OH Aldolase Glyceraldehyde 3-phosphate (G3P) HC-0 CHOH CH₂O-P Isomerase 5 Dihydroxyacetone phosphate (DHAP) CH₂0-P C=O CH₂OH
Transcribed Image Text:5. A mutation causes a change in the shape of the active site of an enzyme involved in glycolysis. This enzyme is an isomerase (see the diagram below). Because of this mutation, this isomerase can no longer convert DHAP into G3P (or G3P into DHAP). What is the total energetic cost during glycolysis due to this mutation? Explain why. You can express the energetic cost in terms of number of ATP molecules per glucose oxidized. You should only consider the cost in glycolysis and none of the processes that occur after that (such as the pyruvate oxidation, the citric acid cycle or the oxidative phosphorylation). Fructose ATP 6-phosphate CH₂0-P CH₂OH H H HO HO H OH GLYCOLYSIS: Energy Investment Phase Fructose 1,6-bisphosphate ADP P-OCH ₂ Phospho- fructokinase 3 H HO H HO H CH₂O-P OH Aldolase Glyceraldehyde 3-phosphate (G3P) HC-0 CHOH CH₂O-P Isomerase 5 Dihydroxyacetone phosphate (DHAP) CH₂0-P C=O CH₂OH
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