5-Bromouracil (BU) resembles thymine sufficiently that BU base-pairs readily with adenine in a DNA helix, and it can readily substitute for thy- mine in DNA replication. However, its electron distribution allows it to resemble cytosine sufficiently that BU can pair with guanine. Show how a few rounds of replication in the presence of BU could convert an A-T base pair to G-C, and identify the products of each round of replication.

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Chapter1: Chemical Foundations
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5-Bromouracil (BU) resembles thymine sufficiently that BU base-pairs
readily with adenine in a DNA helix, and it can readily substitute for thy-
mine in DNA replication. However, its electron distribution allows it to
resemble cytosine sufficiently that BU can pair with guanine. Show how
a few rounds of replication in the presence of BU could convert an A-T
base pair to G-C, and identify the products of each round of replication.
Transcribed Image Text:5-Bromouracil (BU) resembles thymine sufficiently that BU base-pairs readily with adenine in a DNA helix, and it can readily substitute for thy- mine in DNA replication. However, its electron distribution allows it to resemble cytosine sufficiently that BU can pair with guanine. Show how a few rounds of replication in the presence of BU could convert an A-T base pair to G-C, and identify the products of each round of replication.
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