10. Answer ALL parts of this question: DNA is an important drug target. (a) Explain the meaning of primary and secondary structures of DNA. (7 marks) (b) Chain terminators are drugs that act as "false substrates" which are incorporated into a growing DNA chain during replication. Using the diagrams (1) and (II) shown below in Figure Q10(b), demonstrate how the normal DNA replication process occurs and how a drug acts as a chain terminator. A C Drug A (6 marks) DNA template A G C T--- A OH 3' A-T Growing chain G C T- OH A----T DNA template Growing chain (1) Normal replication (II) Chain termination Figure Q10(b)
10. Answer ALL parts of this question: DNA is an important drug target. (a) Explain the meaning of primary and secondary structures of DNA. (7 marks) (b) Chain terminators are drugs that act as "false substrates" which are incorporated into a growing DNA chain during replication. Using the diagrams (1) and (II) shown below in Figure Q10(b), demonstrate how the normal DNA replication process occurs and how a drug acts as a chain terminator. A C Drug A (6 marks) DNA template A G C T--- A OH 3' A-T Growing chain G C T- OH A----T DNA template Growing chain (1) Normal replication (II) Chain termination Figure Q10(b)
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:10. Answer ALL parts of this question:
DNA is an important drug target.
(a)
Explain the meaning of primary and secondary structures of DNA.
(7 marks)
(b)
Chain terminators are drugs that act as "false substrates" which are
incorporated into a growing DNA chain during replication. Using the
diagrams (1) and (II) shown below in Figure Q10(b), demonstrate how
the normal DNA replication process occurs and how a drug acts as a
chain terminator.
A
C
Drug
A
(6 marks)
DNA
template
A
G
C
T--- A
OH
3'
A-T
Growing
chain
G
C
T-
OH
A----T
DNA
template
Growing
chain
(1)
Normal replication
(II)
Chain
termination
Figure Q10(b)
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