3. A missense mutation results in the presence of a different amino acid than wasencoded by the parental sequence. This type of mutation can have a drastic effector no effect at all depending on the importance of the amino acid and the typeof amino acid that replaces it. Some amino acids are structurally similar andmay be able to act as viable substitutes for each other. For example, changingone acidic amino acid to another may not affect the final protein, but changinga polar amino acid to a nonpolar amino acid will likely disrupt the structure.Please explain what mutations occur in HBB gene of abnormal hemoglobin andtheir effect on the function of the protein.

Sickle cell anaemia is an autosomal recessive disorder.

Answered: 3. A missense mutation results in the…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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6. a.) Which part (sugar, phosphate, or nitrogenous base) of the four types of nucleotides differ? b.) Based on the complementary base pairing rules we know that: A(denosine) pairs with _________ , and that G(uanine) pairs with _________.
Part A) In your own words describe what happens in transcription and translation Include which types of nucleic acids are involved in each step Describe the function of each type of nucleic acid in the process of making proteins Part B) Also, explain how two nucleic acids "recognize" or "talk" to each other
8. What is happening to the DNA molecule in the figure? Also, discuss the types and functions of enzyme participating in this step.
13. a. Draw in the corresponding DNA nucleotide that would base pair with the adenine nucleotide shown below using the same level of detail as provided in the image below. Hint: Remember that DNA bases pair in the antiparallel orientation. орасна you A OH H b. How do you know the adenine nucleotide drawn above is from DNA and not RNA?
3. On the diagram below... Using green dashed lines, draw in the hydrogen bonds on the right figure. Using the same color, circle the location of the H-bonds on the left figure. - Using a red pen, circle where the molecules have a negative charge on the right figure. Using the same color, color the area with the negative charge in the left figure. - Is this DNA or RNA? Explain two ways that you know. Clearly label the 5' and 3' ends so that you know which is which! This skill is VERY important. C A A CO G >0.34 nm 3.4 nm HO- HO-P-O O=PIO O=D HO-P-O OH H H O O N- N N N N H H N-H N N H-N H-N H Z-H N FN N 5-1=0 OH O-P-OH O O O-P-OH O -OH
1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). Please EXCLUDE the use of CRISPR from consideration. A. Will you use germline or somatic cell gene therapy? Please NAME and DEFINE the form of gene therapy selected, then explain WHY this is the most appropriate choice.
In the image below, the blue squiggly line represents a folded protein. There are two particular amino acids that are colored red and black in the protein. The structure of each of these two specific amino acids is shown in the indicated box. A mutation occurs in the gene that encodes the protein illustrated above. The result of this mutation is that one of the amino acids above is substituted with another. Specifically, the amino acid whose structure is shaded red above (the one on the left in the illustration) is replaced by the amino acid shown below. Use this information to answer the two questions that follow. Please answer these questions. 1. Based on this description, indicate which type of mutation occurred: missense, nonsense, silent, or indel 2. How would this mutation affect this protein's structure and function? Explain in 2-4 sentences. Be specific, and be sure to include details of these specific amino acids in your response. (I'm giving you the…
1. In the sequence grid below, you will fill in all boxes with end polarity, nucleotide, or amino acid as described below. a. The column to the far left identifies the sequence type. Based on the nucleotides given, fill in the words "template" and "coding" (non-template) for the two DNA strands as soon as you figure out which is which. (hint: look at mRNA) b. In the second and last columns, write the polarity of the ends of each sequence (5', 3', N or C). c. The remaining columns represent transcriptional and translational alignments. Fill in all nucleotides, assuming that the template sequences in the table are read from LEFT to RIGHT d. Using the mRNA codon table provided on the next page, determine the polypeptide sequence. This sequence is from the middle of a coding sequence, therefore you do not need a start sequence. T DNA DNA mRNA codon tRNA anticodon polypeptide DNA DNA mRNA codon tRNA anticodon A C polypeptide GLY A C G e. Repeat steps 1a-1d, but now assume that the template…
Given the following diagram of how protein AWESOME1 binds to it's target DNA, describe the potential effects of each of the 5 mutations shown below. The wild-type sequence of a helix #1 is also shown in the blue box, and all the mutations are in helix #1 (see numbers for identifying particular residues). a helix #1 R(1)-V-I-L-Y-F-W-I-M-Y-F-S-H-Y-W-R(16) #1 Predict the consequence of the following mutations: 1) Arg(1) to Glu 2) Arg(1) to Ala 3) Phe(6) to lle 4) Trp(7) to Phe 5) Met(9) to Pro in

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