3' -T ACATC T T G G C GAC GAC T-5' Mutated DNA Sequence #1: MRNA sequence? (Circle the change) Amino acid sequence? Effects? What kind of mutation is this? 3'-ТАCGA ссттсGсGACGACT-5' Mutated DNA Sequence #2: MRNA sequence? (circle the change) Amino acid sequence? Effects? What kind of mutation is this? 3' -T A CACCTTAG C G AC GAC T-5' Mutated DNA Sequence #3: MRNA sequence? (Circle the change) Amino acid sequence? Will there likely be effects? What kind of mutation is this? 3' -T ACACCT T G G C G A CTAC T-5' Mutated DNA Sequence #4: MRNA sequence? (circle the change) Amino acid sequence? Will there likely be effects? What kind of mutation is this? 3' -T A CA CCT T G A C GAC GAC T-5' Mutated DNA Sequence #5: MRNA sequence? (circle the change) Amino acid sequence? Will there likely be effects? What kind ofmutation is this?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Original Sequence is also attached in the image:

 

3' -T ACATC T T G G C GAC GAC T-5'
Mutated DNA Sequence #1:
MRNA sequence?
(Circle the change)
Amino acid sequence?
Effects?
What kind of mutation is this?
3'-ТАCGA ссттсGсGACGACT-5'
Mutated DNA Sequence #2:
MRNA sequence?
(circle the change)
Amino acid sequence?
Effects?
What kind of mutation is this?
3' -T A CACCTTAG C G AC GAC T-5'
Mutated DNA Sequence #3:
MRNA sequence?
(Circle the change)
Amino acid sequence?
Will there likely be effects?
What kind of mutation is this?
3' -T ACACCT T G G C G A CTAC T-5'
Mutated DNA Sequence #4:
MRNA sequence?
(circle the change)
Amino acid sequence?
Will there likely be effects?
What kind of mutation is this?
3' -T A CA CCT T G A C GAC GAC T-5'
Mutated DNA Sequence #5:
MRNA sequence?
(circle the change)
Amino acid sequence?
Will there likely be effects?
What kind ofmutation is this?
Transcribed Image Text:3' -T ACATC T T G G C GAC GAC T-5' Mutated DNA Sequence #1: MRNA sequence? (Circle the change) Amino acid sequence? Effects? What kind of mutation is this? 3'-ТАCGA ссттсGсGACGACT-5' Mutated DNA Sequence #2: MRNA sequence? (circle the change) Amino acid sequence? Effects? What kind of mutation is this? 3' -T A CACCTTAG C G AC GAC T-5' Mutated DNA Sequence #3: MRNA sequence? (Circle the change) Amino acid sequence? Will there likely be effects? What kind of mutation is this? 3' -T ACACCT T G G C G A CTAC T-5' Mutated DNA Sequence #4: MRNA sequence? (circle the change) Amino acid sequence? Will there likely be effects? What kind of mutation is this? 3' -T A CA CCT T G A C GAC GAC T-5' Mutated DNA Sequence #5: MRNA sequence? (circle the change) Amino acid sequence? Will there likely be effects? What kind ofmutation is this?
Mutations Exercises
You are given the template sequence of an original DNA, and several mutations in the template
(on the next page). Figure out the MRNA sequence and protein sequence of each template, and
then determine the type of mutation that occurred, relative to the original sequence. Choose
from the following mutational types. Classify each mutation at both the DNA and protein level:
A. DNA level
a. Point mutation - transition
b. Point mutation – transversion
c. Frameshift
B. Protein level
a. Synonymous
b. Nonsynonymous – missense
c. Nonsynonymous - nonsense
d. Frameshift
THE GENETIC CODE
SECOND LETTER
A
G
UuU
Phe
Uuc
UAU Tyr
UGU)
Cys
UGC)
UcC
UAC)
Ser
UA
Leu
UUG)
UAA Ochre
(terminator)
Оpal
terminator
UCA
UGA
A
UCG)
UAG Amber
(terminator)
UGG Trp
G
CU
CAU)
His
САС
CU
CGU
CUC
CGC
Arg
CGA
Leu
Pro
CUA
CCA
САА
Gin
CUG,
CCG
CAG
CGG/
ACU
AGU)
Ser
AGC)
AUU
AAU
AUC lleu
A
Asn
AAC
ACC
Thr
AGA
AUA
АCА
AAA
Lys
AAG
Arg
Met
AUG
ACG
AGG)
(initiator)
GCU
GAU
Asp
GAC
GUU
GGU
GUC
Val
GUA
GCC
Ala
GCA
GGC
Gly
GGA
GAA
Glu
GAG)
A
GUG) (initiator) GCG/
GGG
G
Original DNA Sequence:
MRNA Sequence:
3'-T ACACCTT G
CGACT-5'
5'-A UG UGGAA cCG CUG CUGA-3'
Amino Acid Sequence:
Met -
Trp - Asn - Arg
Cys - STOP
FIRST (5') LETTER
THIRD (3') LETTER
Transcribed Image Text:Mutations Exercises You are given the template sequence of an original DNA, and several mutations in the template (on the next page). Figure out the MRNA sequence and protein sequence of each template, and then determine the type of mutation that occurred, relative to the original sequence. Choose from the following mutational types. Classify each mutation at both the DNA and protein level: A. DNA level a. Point mutation - transition b. Point mutation – transversion c. Frameshift B. Protein level a. Synonymous b. Nonsynonymous – missense c. Nonsynonymous - nonsense d. Frameshift THE GENETIC CODE SECOND LETTER A G UuU Phe Uuc UAU Tyr UGU) Cys UGC) UcC UAC) Ser UA Leu UUG) UAA Ochre (terminator) Оpal terminator UCA UGA A UCG) UAG Amber (terminator) UGG Trp G CU CAU) His САС CU CGU CUC CGC Arg CGA Leu Pro CUA CCA САА Gin CUG, CCG CAG CGG/ ACU AGU) Ser AGC) AUU AAU AUC lleu A Asn AAC ACC Thr AGA AUA АCА AAA Lys AAG Arg Met AUG ACG AGG) (initiator) GCU GAU Asp GAC GUU GGU GUC Val GUA GCC Ala GCA GGC Gly GGA GAA Glu GAG) A GUG) (initiator) GCG/ GGG G Original DNA Sequence: MRNA Sequence: 3'-T ACACCTT G CGACT-5' 5'-A UG UGGAA cCG CUG CUGA-3' Amino Acid Sequence: Met - Trp - Asn - Arg Cys - STOP FIRST (5') LETTER THIRD (3') LETTER
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